ReviewNutrients2019
Thirst and Drinking Paradigms: Evolution from Single Factor Effects to Brainwide Dynamic Networks.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Demographic, perioperative, biochemical and illness-severity predictors of thirst in critically ill patients: a systematic review and meta-analysis.Internal medicine journal · 2026Pooled it
- Study on the Differences in the Thirst-Quenching Effects of Different Beverages Supplemented Before Exercise: A Randomized Crossover Trial.Nutrients · 2025Trial
- The Effect of Fluid Availability on Consumption and Perceptual Measures during Aerobic Exercise.International journal of environmental research and public health · 2023Trial
- Thirst level trajectories and influencing factors in critically ill patients based on a group-based trajectory model: A prospective observational study.International journal of nursing studies advances · 2026Article
- Implementing a Safety Protocol for Thirst Management to Improve Postoperative Thirst Using the Iowa Model of Evidence-Based Practice: A Propensity Score-Matched Evaluation.Journal of clinical nursing · 2026Article
- Persistent Thirst and Its Clinical Correlates in Critically Ill Adults: A Prospective Observational Study.Nursing in critical care · 2026Observational
- Association between sleep duration and thirst in a nationally representative cross-sectional survey.Scientific reports · 2026Article
- Core-Perception Coupling: Relationships among Core Temperature, the Rating of Perceived Exertion, and Thirst during Moderate Continuous Exercise under Different Hydration Status.Journal of human kinetics · 2026Article
- Hydration status, thirst discomfort, and ocular surface health among older adults in Türkiye: a cross-sectional study.BMC geriatrics · 2026Article
- Body fluid regulation.Current opinion in neurobiology · 2025Review
- Exercise-Associated Hyponatremia: Serum Sodium, Symptomatology, Severity, and Sport Specificity.Open access journal of sports medicine · 2025Review
- Reference Values for Hydration Biomarkers: Optimizing Athletic Performance and Recovery.Open access journal of sports medicine · 2025Review
- Customizing individual heat mitigation strategies to optimize performance in elite athletes.Frontiers in physiology · 2025Review
- Development of safety protocols for managing thirst in post-extubated and tracheostomized patients.Revista latino-americana de enfermagem · 2025Article
- Relationships between Morning Thirst and Later Hydration Status and Total Water Intake.Nutrients · 2024Article
- SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death.Medical sciences (Basel, Switzerland) · 2022Review
- Article
- Fluid Restriction Negatively Influences Perceived Morning Alertness and Visuomotor Ability.International journal of environmental research and public health · 2021Article
- Nutritional approaches to counter performance constraints in high-level sports competition.Experimental physiology · 2021Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The motivation to seek and consume water is an essential component of human fluid-electrolyte homeostasis, optimal function, and health. This review describes the evolution of concepts regarding thirst and drinking behavior, made possible by magnetic resonance imaging, animal models, and novel laboratory techniques. The earliest thirst paradigms focused on single factors such as dry mouth and loss of water from tissues. By the end of the 19th century, physiologists proposed a thirst center in the brain that was verified in animals 60 years later. During the early- and mid-1900s, the influences of gastric distention, neuroendocrine responses, circulatory properties (i.e., blood pressure, volume, concentration), and the distinct effects of intracellular dehydration and extracellular hypovolemia were recognized. The majority of these studies relied on animal models and laboratory methods such as microinjection or lesioning/oblation of specific brain loci. Following a quarter century (1994-2019) of human brain imaging, current research focuses on networks of networks, with thirst and satiety conceived as hemispheric waves of neuronal activations that traverse the brain in milliseconds. Novel technologies such as chemogenetics, optogenetics, and neuropixel microelectrode arrays reveal the dynamic complexity of human thirst, as well as the roles of motivation and learning in drinking behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.