ArticleMaterials (Basel, Switzerland)2019
Niobium-Treated Titanium Implants with Improved Cellular and Molecular Activities at the Tissue-Implant Interface.
Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Biocompatibility Evaluation of Novel Experimental Titanium Alloys for Dental Implants.Dentistry journal · 2025Article
- Exploring the Broad Spectrum of Titanium-Niobium Implants and Hydroxyapatite Coatings-A Review.Materials (Basel, Switzerland) · 2024Review
- Dental Implants: Modern Materials and Methods of Their Surface Modification.Materials (Basel, Switzerland) · 2023Review
- Transition metals in angiogenesis - A narrative review.Materials today. Bio · 2023Review
- Fibroblast Cell Responses to Vanadium and Niobium Titanium Alloys: A Biocompatibility Study.ACS omega · 2023Article
- Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy.Materials (Basel, Switzerland) · 2023Article
- Niobium: The Focus on Catalytic Application in the Conversion of Biomass and Biomass Derivatives.Molecules (Basel, Switzerland) · 2023Review
- Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery Systems.Journal of functional biomaterials · 2023Article
- Clickable Polysaccharides for Biomedical Applications: A Comprehensive Review.Progress in polymer science · 2022Article
- In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility.Biomedicines · 2022Article
- Feasibility analysis of an ultrasound on line diagnostic approach for oral and bone surgery.Scientific reports · 2022Article
- Synthesis and Characterization of a Novel Biocompatible Alloy, Ti-Nb-Zr-Ta-Sn.International journal of molecular sciences · 2021Article
- Influence of Bone Definition and Finite Element Parameters in Bone and Dental Implants Stress: A Literature Review.Biology · 2020Review
- Evaluation of the Physicochemical and Antibacterial Properties of Experimental Adhesives Doped with Lithium Niobate.Polymers · 2020Article
- Mechanism of Fatigue Crack Growth in Biomedical Alloy Ti-27Nb.Materials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been several attempts to improve the cellular and molecular interactions at the tissue-implant interface. Here, the biocompatibility of titanium-based implants (e.g., Grade 2 Titanium alloy (Ti-40) and titanium-niobium alloy (Ti-Nb)) has been assessed using different cellular and molecular examinations. Cell culture experiments were performed on three substrates: Ti-40, Ti-Nb, and tissue culture polystyrene as control. Cells number and growth rate were assessed by cell counting in various days and cell morphology was monitored using microscopic observations. The evaluation of cells' behavior on the surface of the implants paves the way for designing appropriate biomaterials for orthopedic and dental applications. It was observed that the cell growth rate on the control sample was relatively higher than that of the Ti-40 and Ti-Nb samples because of the coarse surface of the titanium-based materials. On the other hand, the final cell population was higher for titanium-based implants; this difference was attributed to the growth pattern, in which cells were not monolayered on the surface. Collagen I was not observed, while collagen III was secreted. Furthermore, interleukin (IL)-6 and vascular endothelial growth factor (VEGF) secretion were enhanced, and IL-8 secretion decreased. Moreover, various types of cells can be utilized with a series of substrates to unfold the cell behavior mechanism and cell-substrate interaction.
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