Evidence map›Paper›PMID 31766592›Full record

ReviewNutrients2019

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration.

Emily R Leeming, Abigail J Johnson, Tim D Spector, Caroline I Le Roy

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05291299 (Anti-Inflammatory Dietary Intervention for Rheumatoid Arthritis), which is not on this map. Cited by 461 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
461citing papers in PubMed, 8 pooled it
24.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05291299 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Anti-Inflammatory Dietary Intervention for Rheumatoid Arthritis

TypeinterventionalSponsorAttune Health Research, Inc.Ran2022 to 2025Enrolled32ConditionsRheumatoid ArthritisArmsAnti-inflammatory diet, Control/Standard of Care
3 · Its place in the literature

Who cites it

461 citing papers in PubMed, 8 syntheses or guidelines pooled it, 786 citations in OpenAlex.

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  4. Prevalence of enterotoxigenicFrontiers in cellular and infection microbiology · 2025
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401 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Emily R LeemingDepartment of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London SE1 7EH, UK.
Abigail J JohnsonBioTechnology Institute, University of Minnesota, Saint Paul, MN 55108, USA.ORCID 0000-0002-5998-4724
Tim D SpectorDepartment of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London SE1 7EH, UK.
Caroline I Le RoyDepartment of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London SE1 7EH, UK.ORCID 0000-0002-0341-751X
King's College London · GBUniversity of Minnesota · US

Funding

Chronic Disease Research Foundation N/AMedical Research Council MR/N01183X/1Medical Research Council MR/N030125/1
6 · The paper itself

Abstract

The human gut is inhabited by trillions of microorganisms composing a dynamic ecosystem implicated in health and disease. The composition of the gut microbiota is unique to each individual and tends to remain relatively stable throughout life, yet daily transient fluctuations are observed. Diet is a key modifiable factor influencing the composition of the gut microbiota, indicating the potential for therapeutic dietary strategies to manipulate microbial diversity, composition, and stability. While diet can induce a shift in the gut microbiota, these changes appear to be temporary. Whether prolonged dietary changes can induce permanent alterations in the gut microbiota is unknown, mainly due to a lack of long-term human dietary interventions, or long-term follow-ups of short-term dietary interventions. It is possible that habitual diets have a greater influence on the gut microbiota than acute dietary strategies. This review presents the current knowledge around the response of the gut microbiota to short-term and long-term dietary interventions and identifies major factors that contribute to microbiota response to diet. Overall, further research on long-term diets that include health and microbiome measures is required before clinical recommendations can be made for dietary modulation of the gut microbiota for health.

Indexed as

DietDuration of TherapyGastrointestinal MicrobiomeCircadian RhythmDiet, HealthyDiet TherapyHumansNutrientsPrebioticsProbioticsSeasonsSynbioticsNutrientsPrebioticsdietdietary interventiondurationgut microbiotahealthnutrition

Identifiers

PMID31766592
PMCPMC6950569
OpenAlexW2990512216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.