Evidence map›Paper›PMID 31766582›Full record

ArticleGenes2019

The Hearing Impairment Ontology: A Tool for Unifying Hearing Impairment Knowledge to Enhance Collaborative Research.

Jade Hotchkiss, Noluthando Manyisa, Samuel Mawuli Adadey, Oluwafemi Gabriel Oluwole, Edmond Wonkam, Khuthala Mnika, Abdoulaye Yalcouye, Victoria Nembaware, Melissa Haendel, Nicole Vasilevsky and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The identification of novel missense variant inOpen medicine (Warsaw, Poland) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jade HotchkissDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.
Noluthando ManyisaDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.
Samuel Mawuli AdadeyDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.
Oluwafemi Gabriel OluwoleDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.
Edmond WonkamDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.
Khuthala MnikaDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.
Abdoulaye YalcouyeDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.
Victoria NembawareDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.
Melissa HaendelOregon Health & Science University, Portland, OR 97217, USA.
Nicole VasilevskyOregon Health & Science University, Portland, OR 97217, USA.
Nicola J MulderComputational Biology Division, Department of Integrative Biomedical Sciences, University of Cape Town, Health Sciences Campus. Anzio Rd, Observatory, 7925, South Africa.
Simon JuppEuropean Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
Ambroise WonkamDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.
Gaston K MazanduDivision of Human Genetics, Department of Pathology, University of Cape Town, Health Sciences Campus, Anzio Rd, Observatory, 7925, South Africa.

Funding

Sickle Africa Data Coordinating CenterU24HL135600 · NHLBI · UNIVERSITY OF CAPE TOWN · PI MULDER, NICOLA, WONKAM, AMBROISE · 2017 to 2025
$8.6M
Hearing Impairment Genetics Studies in Africa (HI-GENES Africa)U01HG009716 · NHGRI · UNIVERSITY OF CAPE TOWN · PI WONKAM, AMBROISE · 2017 to 2021
$1.2M
NHGRI NIH HHS U01 HG009716NHLBI NIH HHS U24 HL135600NIH HHS 1U01HG007459-01NIH HHS 1U54HG009790-01NIH HHS U01-HG-009716Wellcome Trust H3A/18/001
6 · The paper itself

Abstract

Hearing impairment (HI) is a common sensory disorder that is defined as the partial or complete inability to detect sound in one or both ears. This diverse pathology is associated with a myriad of phenotypic expressions and can be non-syndromic or syndromic. HI can be caused by various genetic, environmental, and/or unknown factors. Some ontologies capture some HI forms, phenotypes, and syndromes, but there is no comprehensive knowledge portal which includes aspects specific to the HI disease state. This hampers inter-study comparability, integration, and interoperability within and across disciplines. This work describes the HI Ontology (HIO) that was developed based on the Sickle Cell Disease Ontology (SCDO) model. This is a collaboratively developed resource built around the 'Hearing Impairment' concept by a group of experts in different aspects of HI and ontologies. HIO is the first comprehensive, standardized, hierarchical, and logical representation of existing HI knowledge. HIO allows researchers and clinicians alike to readily access standardized HI-related knowledge in a single location and promotes collaborations and HI information sharing, including epidemiological, socio-environmental, biomedical, genetic, and phenotypic information. Furthermore, this ontology illustrates the adaptability of the SCDO framework for use in developing a disease-specific ontology.

Indexed as

Biological OntologiesHearing LossBiomedical ResearchCooperative BehaviorHumansKnowledgedata harmonizationhearing impairmenthearing lossmeta-analysisontology

Identifiers

PMID31766582
PMCPMC6947307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.