Evidence map›Paper›PMID 31766577›Full record

ArticleBiomolecules2019

The Plasma Factor XIII Heterotetrameric Complex Structure: Unexpected Unequal Pairing within a Symmetric Complex.

Sneha Singh, Alexis Nazabal, Senthilvelrajan Kaniyappan, Jean-Luc Pellequer, Alisa S Wolberg, Diana Imhof, Johannes Oldenburg, Arijit Biswas

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Sneha SinghInstitute of Experimental Hematology and Transfusion medicine, University Hospital of Bonn, Sigmund-Freud Street 25, 53127 Bonn, Germany.
Alexis NazabalCovalX, Schützengasse 2, CH-8001 Zürich, Switzerland.
Senthilvelrajan KaniyappanGerman Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany.
Jean-Luc PellequerUniv. Grenoble Alpes, CEA, CNRS, IBS, F-38000 Grenoble, France.
Alisa S WolbergDepartment of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, 8018A Mary Ellen Jones Building, Chapel Hill, NC 27599-7035, USA.
Diana ImhofPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Johannes OldenburgInstitute of Experimental Hematology and Transfusion medicine, University Hospital of Bonn, Sigmund-Freud Street 25, 53127 Bonn, Germany.
Arijit BiswasInstitute of Experimental Hematology and Transfusion medicine, University Hospital of Bonn, Sigmund-Freud Street 25, 53127 Bonn, Germany.
University Hospital Bonn · DECentre National de la Recherche Scientifique · FRETH Zurich · CHGerman Center for Neurodegenerative Diseases · DEUniversity of Bonn · DEUniversity of North Carolina at Chapel Hill · US

Funding

Fibrinogen and Factor XIII in Venous ThrombosisR01HL126974 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alisa S. Wolberg · 2016 to 2026
$4.4M
NHLBI NIH HHS R01 HL126974
6 · The paper itself

Abstract

Factor XIII (FXIII) is a predominant determinant of clot stability, strength, and composition. Plasma FXIII circulates as a pro-transglutaminase with two catalytic A subunits and two carrier-protective B subunits in a heterotetramer (FXIII-A

Indexed as

Protein MultimerizationCalciumFactor XIIIHEK293 CellsHumansMolecular Docking SimulationProtein ConformationProtein SubunitsThermodynamicsThrombinCalciumFactor XIIIProtein SubunitsThrombinatomic force microscopycoagulation factor XIII complexcross-linking mass spectrometryHADDOCK flexible dockingisothermal titration calorimetrymolecular dynamics simulationthreaded modeling

Identifiers

PMID31766577
PMCPMC6995596
OpenAlexW2989720905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.