ArticleBiomolecules2019
Preparation and Evaluation of the ZnO NP-Ampicillin/Sulbactam Nanoantibiotic: Optimization of Formulation Variables Using RSM Coupled GA Method and Antibacterial Activities.
Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Statistical optimization of eco-friendly synthesized silver nanoparticles using Discopodium penninervium Hochst leaf extract for enhanced antimicrobial efficacy.Scientific reports · 2025Article
- Antifungal activity ofFrontiers in microbiology · 2024Article
- Molecular Dynamic Analysis of Carbapenem-ResistantMolecules (Basel, Switzerland) · 2023Article
- Sustainable green approach to synthesize FeScientific reports · 2021Article
- Biosynthesis of Zinc Oxide Nanoparticles fromMolecules (Basel, Switzerland) · 2021Article
- Antimicrobial Activity of Zinc Oxide Nano/Microparticles and Their Combinations against Pathogenic Microorganisms for Biomedical Applications: From Physicochemical Characteristics to Pharmacological Aspects.Nanomaterials (Basel, Switzerland) · 2021Review
- Effects of Zinc Oxide Nanoparticles Synthesized UsingFrontiers in cellular and infection microbiology · 2021Article
- The Biomolecular Spectrum Drives Microbial Biology and Functions in Agri-Food-Environments.Biomolecules · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticles (NPs) possessing antibacterial activity represent an effective way of overcoming bacterial resistance. In the present work, we report a novel formulation of a nanoantibiotic formed using Ampicillin/sulbactam (Ams) and a zinc oxide nanoparticle (ZnO NP). 'ZnO NP-Ams' nanoantibiotic formulation is optimized using response surface methodology coupled genetic algorithm approach. The optimized formulation of nanoantibiotic (ZnO NP: 49.9 μg/mL; Ams: 33.6 μg/mL; incubation time: 27 h) demonstrated 15% enhanced activity compared to the unoptimized formulation against
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Registered trials
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