Evidence map›Paper›PMID 31766565›Full record

ArticleInternational journal of molecular sciences2019

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.

Nesli-Ece Sen, Aleksandar Arsovic, David Meierhofer, Susanne Brodesser, Carola Oberschmidt, Júlia Canet-Pons, Zeynep-Ece Kaya, Melanie-Vanessa Halbach, Suzana Gispert, Konrad Sandhoff and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from ENIGMA-Ataxia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Sphingolipid metabolism governs Purkinje cell patterned degeneration inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Mid-Gestation lethality ofInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Nesli-Ece SenExperimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Aleksandar ArsovicExperimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
David MeierhoferMax Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany.
Susanne BrodesserMembrane Biology and Lipid Biochemistry Unit, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.ORCID 0000-0001-5631-0663
Carola OberschmidtExperimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Júlia Canet-PonsExperimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Zeynep-Ece KayaExperimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Melanie-Vanessa HalbachExperimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Suzana GispertExperimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Konrad SandhoffMembrane Biology and Lipid Biochemistry Unit, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Georg AuburgerExperimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Goethe University Frankfurt · DEUniversity of Bonn · DEMax Planck Institute for Molecular Genetics · DE

Funding

Deutsche Forschungsgemeinschaft AU96 11/1Deutsche Forschungsgemeinschaft AU96 11/3
6 · The paper itself

Abstract

Ataxin-2 (human gene symbol

Indexed as

AnimalsAtaxin-2CeramidesDisease Models, AnimalEye ProteinsHumansLipid MetabolismMembrane ProteinsMice, KnockoutSphingomyelin PhosphodiesteraseSphingomyelinsSphingosine N-AcyltransferaseSpinocerebellar AtaxiasTrinucleotide Repeat ExpansionAtaxin-2CeramidesCers2 protein, mouseElovl4 protein, mouseEye ProteinsMembrane ProteinsSmpd3 protein, mouseSphingomyelin PhosphodiesteraseSphingomyelinsSphingosine N-Acyltransferaseacid sphingomyelinase (ASMaseamyotrophic lateral sclerosis (ALS)ceramide synthase (CERS2/CERS1)fatty acid elongase (Elovl1/4/5)leukodystrophyneutral ceramidase (Asah2)neutral sphingomyelinase (Smpd3)olivo-ponto-cerebellar atrophy (OPCA)SCA34SCA38serine palmitoyltransferase 2 (Sptlc2)Smpd1)

Identifiers

PMID31766565
PMCPMC6928749
OpenAlexW2990838235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.