Evidence map›Paper›PMID 31766534›Full record

ArticleBiomolecules2019

Clerodane Diterpene Ameliorates Inflammatory Bowel Disease and Potentiates Cell Apoptosis of Colorectal Cancer.

Jia-Huei Zheng, Shian-Ren Lin, Feng-Jen Tseng, May-Jywan Tsai, Sheng-I Lue, Yi-Chen Chia, Mindar Woon, Yaw-Syan Fu, Ching-Feng Weng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. 5Acta pharmaceutica Sinica. B · 2024
    Article
  4. Phytochemicals fromMolecules (Basel, Switzerland) · 2021
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jia-Huei ZhengDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan.
Shian-Ren LinDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan.
Feng-Jen TsengDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan.
May-Jywan TsaiDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei City 11217, Taiwan.
Sheng-I LueDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan.
Yi-Chen ChiaDepartment of Food Science & Technology, Tajen University, Pingtung, 90741, Taiwan.
Mindar WoonDepartment of Radiation Oncology, Yeezen Hospital, Taoyuan 32645, Taiwan.
Yaw-Syan FuDepartment of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Ching-Feng WengDepartment of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Kaohsiung Medical University · TWNational Dong Hwa University · TWTaipei Veterans General Hospital · TWTajen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is general term for ulcerative colitis and Crohn's disease, which is chronic intestinal and colorectal inflammation caused by microbial infiltration or immunocyte attack. IBD is not curable, and is highly susceptible to develop into colorectal cancer. Finding agents to alleviate these symptoms, as well as any progression of IBD, is a critical effort. This study evaluates the anti-inflammation and anti-tumor activity of 16-hydroxycleroda-3,13-dien-15,16-olide (HCD) in in vivo and in vitro assays. The result of an IBD mouse model induced using intraperitoneal chemical azoxymethane (AOM)/dextran sodium sulfate (DSS) injection showed that intraperitoneal HCD adminstration could ameliorate the inflammatory symptoms of IBD mice. In the in vitro assay, cytotoxic characteristics and retained signaling pathways of HCD treatment were analyzed by MTT assay, cell cycle analysis, and Western blotting. From cell viability determination, the IC

Indexed as

ApoptosisAnimalsAzoxymethaneBiomarkers, TumorCaco-2 CellsCell CycleCell ProliferationCell SurvivalColorectal NeoplasmsDextran SulfateDiterpenes, ClerodaneFluorouracilHT29 CellsHumansInflammationInflammatory Bowel DiseasesAzoxymethaneBiomarkers, TumorDextran SulfateDiterpenes, ClerodaneFluorouracilcolorectal cancerditerpenesherbal medicine.inflammatory bowel diseasesPolyalthia longifolia

Identifiers

PMID31766534
PMCPMC6995628
OpenAlexW2991417580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.