Evidence map›Paper›PMID 31766444›Full record

ArticleMolecules (Basel, Switzerland)2019

Design and Synthesis of New 6-Nitro and 6-Amino-3,3a,4,5-Tetrahydro-2

Viviana Cuartas, María Del Pilar Crespo, Eva-María Priego, Leentje Persoons, Dirk Daelemans, María-José Camarasa, Braulio Insuasty, María-Jesús Pérez-Pérez

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Viviana CuartasGrupo de Investigación de Compuestos Heterocíclicos, Departamento de Química, Universidad del Valle, A. A., Cali 25360, Colombia.
María Del Pilar CrespoGrupo de Biotecnología e Infecciones Bacterianas, Departamento de Microbiología, Universidad del Valle, Cali 760043, Colombia.
Eva-María PriegoInstituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Leentje PersoonsKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Dirk DaelemansKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
María-José CamarasaInstituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Braulio InsuastyGrupo de Investigación de Compuestos Heterocíclicos, Departamento de Química, Universidad del Valle, A. A., Cali 25360, Colombia.
María-Jesús Pérez-PérezInstituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Instituto de Química Médica · ESUniversidad del Valle · CORega Institute for Medical Research · BE

Funding

COLCIENCIAS 110680864255CSIC PIE-201680E079MINECO/FEDER SAF2015-64629-C2-1-RScience, Technology and Innovation Fund-General Royalties System (FCTeI-SGR), Colombia BPIN 2013000100007Universidad del Valle CIAM-2017
6 · The paper itself

Abstract

New substituted benzo[g]indazoles functionalized with a 6-nitro and 6-amino groups have been synthesized by the reaction of benzylidene tetralones with hydrazine in acetic acid. The resulting conformationally-constrained compounds were evaluated for their antiproliferative activity against selected cancer cell lines. The nitro-based indazoles

Indexed as

Drug DesignAnti-Bacterial AgentsAntineoplastic AgentsBacteriaCell ProliferationHemolysisHumansIndazolesNeoplasmsTumor Cells, CulturedAnti-Bacterial AgentsAntineoplastic AgentsIndazoles2-benzylidene-1-tetraloneantibacterial activityantiproliferative activityindazole

Identifiers

PMID31766444
PMCPMC6930490
OpenAlexW2991394913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.