Evidence map›Paper›PMID 31766319›Full record

ReviewCells2019

Mitochondrial MiRNA in Cardiovascular Function and Disease.

Rui Song, Xiang-Qun Hu, Lubo Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Pathogenic mechanisms in Fabry disease.Frontiers in medicine · 2026
    Review
  3. RNA Therapeutics in Heart Failure.Journal of cardiovascular translational research · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease.The Journal of pharmacology and experimental therapeutics · 2023
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rui SongLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Xiang-Qun HuLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Lubo ZhangLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Loma Linda University · US

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2016 to 2020
$6.3M
Uterine Arterial Spontaneous Transient Outward Currents in PregnancyR01HL137649 · NHLBI · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2017 to 2020
$1.6M
NHLBI NIH HHS R01 HL137649NICHD NIH HHS P01 HD083132
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs functioning as crucial post-transcriptional regulators of gene expression involved in cardiovascular development and health. Recently, mitochondrial miRNAs (mitomiRs) have been shown to modulate the translational activity of the mitochondrial genome and regulating mitochondrial protein expression and function. Although mitochondria have been verified to be essential for the development and as a therapeutic target for cardiovascular diseases, we are just beginning to understand the roles of mitomiRs in the regulation of crucial biological processes, including energy metabolism, oxidative stress, inflammation, and apoptosis. In this review, we summarize recent findings regarding how mitomiRs impact on mitochondrial gene expression and mitochondrial function, which may help us better understand the contribution of mitomiRs to both the regulation of cardiovascular function under physiological conditions and the pathogenesis of cardiovascular diseases.

Indexed as

ApoptosisCardiovascular DiseasesEnergy MetabolismGene Expression RegulationGenome, MitochondrialHumansInflammationMicroRNAsMitochondriaMitochondrial ProteinsOxidative StressMicroRNAsMitochondrial Proteinscardiovascular diseasemiRNAmitochondriamitomiR

Identifiers

PMID31766319
PMCPMC6952824
OpenAlexW2989873541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.