Evidence map›Paper›PMID 31766266›Full record

ArticleInternational journal of molecular sciences2019

DEK Is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma.

Kam-Fai Lee, Ming-Ming Tsai, Chung-Ying Tsai, Chung-Guei Huang, Yu-Hsiang Ou, Ching-Chuan Hsieh, Hsi-Lung Hsieh, Chia-Siu Wang, Kwang-Huei Lin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Current issues in molecular biology · 2024
    Article
  4. Circulating Proteins as Diagnostic Markers in Gastric Cancer.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Anticancer Effects ofJournal of Cancer · 2021
    Article
  13. Article
  14. Analysis and external validation of a nomogram to predict peritoneal dissemination in gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kam-Fai LeeDepartment of Pathology, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
Ming-Ming TsaiDepartment of Nursing, Division of Basic Medical Sciences, Chang-Gung University of Science and Technology, Taoyuan 333, Taiwan.ORCID 0000-0002-4495-6616
Chung-Ying TsaiDepartment of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan.
Chung-Guei HuangDepartment of Medical Biotechnology and Laboratory Science, and Graduate Institute of Biomedical Science, Chang Gung University, Taoyuan 333, Taiwan.
Yu-Hsiang OuDepartment of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan.
Ching-Chuan HsiehDepartment of General Surgery, Chang Gung Memorial Hospital, Chia-yi 613, Taiwan.
Hsi-Lung HsiehDepartment of Nursing, Division of Basic Medical Sciences, Chang-Gung University of Science and Technology, Taoyuan 333, Taiwan.ORCID 0000-0001-8302-2472
Chia-Siu WangDepartment of General Surgery, Chang Gung Memorial Hospital, Chia-yi 613, Taiwan.
Kwang-Huei LinResearch Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.ORCID 0000-0002-5649-2222
Chang Gung University · TWChang Gung University of Science and Technology · TWChang Gung Memorial Hospital · TWChiayi Chang Gung Memorial Hospital · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPF1G0011Chang Gung Memorial Hospital, Linkou CMRPF1G0251Chang Gung Memorial Hospital, Linkou CMRPF1I0031Chang Gung Memorial Hospital, Linkou CMRPG6F0621Chang Gung Memorial Hospital, Linkou CMRPG6F0622Chang Gung Memorial Hospital, Linkou CMRPG6F623Chang Gung University of Science and Technology ZRRPF3J0081Ministry of Science and Technology MOST 105-2314-B-182A-044Ministry of Science and Technology MOST 106-2314-B-182A-130
6 · The paper itself

Abstract

Gastric cancer (GC) is the second most widespread cause of cancer-related mortality worldwide. The discovery of novel biomarkers of oncoproteins can facilitate the development of therapeutic strategies for GC treatment. In this study, we identified novel biomarkers by integrating isobaric tags for relative and absolute quantitation (iTRAQ), a human plasma proteome database, and public Oncomine datasets to search for aberrantly expressed oncogene-associated proteins in GC tissues and plasma. One of the most significantly upregulated biomarkers, DEK, was selected and its expression validated. Our immunohistochemistry (IHC) (

Indexed as

AgedBiomarkers, TumorCell Line, TumorCell MovementChromosomal Proteins, Non-HistoneFemaleHumansMaleMiddle AgedNeoplasm MetastasisOncogene ProteinsPoly-ADP-Ribose Binding ProteinsPrognosisStomach NeoplasmsSurvival AnalysisBiomarkers, TumorChromosomal Proteins, Non-HistoneDEK protein, humanOncogene ProteinsPoly-ADP-Ribose Binding ProteinsbiomarkerDEKdiagnosisgastric cancermetastasisprognosis

Identifiers

PMID31766266
PMCPMC6888682
OpenAlexW2984953312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.