ArticleHealthcare (Basel, Switzerland)2019
Randomized Single-Case Experimental Designs in Healthcare Research: What, Why, and How?
Article in Healthcare (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Components of Behavioral Parent Training for Children With Attention-Deficit/Hyperactivity Disorder: A Series of Replicated Single-Case Experiments.Behavior modification · 2023Trial
- Article
- Examining the utility of process-focused data driven psychological networks for individualizing psychological treatment in chronic pain-A single case experiment testing the centrality hypothesis.Frontiers in psychology · 2026Article
- Treating prolonged grief disorder with CBT for insomnia: A replicated single-case experimental study protocol.PloS one · 2026Article
- Article
- Effectiveness and Cost-Effectiveness of Using a Social Robot in Residential Care for Individuals With Challenges in Daily Structure and Planning: Protocol for a Multiple-Baseline Single Case Trial and Health Economic Evaluation.JMIR research protocols · 2025Article
- Using Behavioural Skills Training with Healthcare Staff to Promote Greater Independence for People Living with Dementia: A Randomised Single-Case Experimental Design.Behavioral sciences (Basel, Switzerland) · 2025Article
- Multimodal Physiotherapist Intervention Program for Physical and Psychological Functioning in Children with Chronic Pain: Guiding Physiotherapy Intervention with the Pediatric Pain Screening Tool with Recommendations for Clinical Practice.Journal of clinical medicine · 2025Article
- Leveraging Single-Case Experimental Designs to Promote Personalized Psychological Treatment: Step-by-Step Implementation Protocol with Stakeholder Involvement of an Outpatient Clinic for Personalized Psychotherapy.Administration and policy in mental health · 2024Article
- Effectiveness of the mobile Stress Autism Mate Junior application in reducing stress and improving quality of life in adolescents with autism: a pilot study.Frontiers in psychiatry · 2024Article
- The effect of the stress autism mate app on perceived stress, coping, and resilience in adults with autism: a single-case experimental design.Frontiers in psychiatry · 2024Article
- Intramuscular Electrical Stimulation for the Treatment of Trigger Points in Patients with Chronic Migraine: A Protocol for a Pilot Study Using a Single-Case Experimental Design.Medicina (Kaunas, Lithuania) · 2023Article
- Clinical Research: A Review of Study Designs, Hypotheses, Errors, Sampling Types, Ethics, and Informed Consent.Cureus · 2023Review
- Protocol for single case experimental design for yoga and sleep quality and inflammation: A two-hit model of sleep intervention.Contemporary clinical trials communications · 2022Article
- Article
- N-of-1 Trials in Healthcare.Healthcare (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Health problems are often idiosyncratic in nature and therefore require individualized diagnosis and treatment. In this paper, we show how single-case experimental designs (SCEDs) can meet the requirement to find and evaluate individually tailored treatments. We give a basic introduction to the methodology of SCEDs and provide an overview of the available design options. For each design, we show how an element of randomization can be incorporated to increase the internal and statistical conclusion validity and how the obtained data can be analyzed using visual tools, effect size measures, and randomization inference. We illustrate each design and data analysis technique using applied data sets from the healthcare literature.
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