Evidence map›Paper›PMID 31766140›Full record

ArticleMolecules (Basel, Switzerland)2019

Kinetic Modelling of [

Lars Jødal, Anne Roivainen, Vesa Oikonen, Sirpa Jalkanen, Søren B Hansen, Pia Afzelius, Aage K O Alstrup, Ole L Nielsen, Svend B Jensen

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. [RMD open · 2026
    Article
  2. Observational
  3. Review
  4. Review
  5. Review
  6. Radiotracers for Bone Marrow Infection Imaging.Molecules (Basel, Switzerland) · 2021
    Review
  7. First-in-Humans Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  8. Radioactive Molecules 2019-2020.Molecules (Basel, Switzerland) · 2021
    Article
  9. Attempts to TargetMolecules (Basel, Switzerland) · 2020
    Article
  10. Carbon Nanomaterials for Sorption ofNanomaterials (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Lars JødalDepartment of Nuclear Medicine, Aalborg University Hospital, DK-9000 Aalborg, Denmark.ORCID 0000-0002-6811-0172
Anne RoivainenTurku PET Centre, Turku University Hospital, FI-20520 Turku, Finland.ORCID 0000-0002-4006-7977
Vesa OikonenTurku PET Centre, Turku University Hospital, FI-20520 Turku, Finland.ORCID 0000-0002-1947-0219
Sirpa JalkanenMediCity Research Laboratory and Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland.
Søren B HansenDepartment of Nuclear Medicine and PET, Aarhus University Hospital, DK-8200 Aarhus, Denmark.ORCID 0000-0003-2003-7292
Pia AfzeliusNorth Zealand Hospital, Hillerød, Copenhagen University Hospital, DK-3400 Hillerød, Denmark.
Aage K O AlstrupDepartment of Nuclear Medicine and PET, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Ole L NielsenDepartment of Veterinary and Animal Sciences, University of Copenhagen, DK-1870 Copenhagen, Denmark.
Svend B JensenDepartment of Nuclear Medicine, Aalborg University Hospital, DK-9000 Aalborg, Denmark.ORCID 0000-0001-8575-3703
University of Turku · FIAalborg University Hospital · DKAarhus University Hospital · DKCopenhagen University Hospital · DKUniversity of Copenhagen · DK

Funding

Jane ja Aatos Erkon Säätiö to ARTeknologi og Produktion, Det Frie Forskningsråd 0602-01911B (11-107077)
6 · The paper itself

Abstract

background[

methodsEight pigs with osteomyelitis and soft tissue infections in the right hind limb were dynamically PET scanned for 60 min along with arterial blood sampling. The fraction of radioactivity in the blood accounted for by the parent tracer was evaluated with radio-high-performance liquid chromatography. One- and two-tissue compartment models were used for pharmacokinetic evaluation. Post-mortem soft tissue samples from one pig were analysed with anti-VAP-1 immunofluorescence. In each analysis, the animal's non-infected left hind limb was used as a control.

resultsTracer uptake was elevated in soft tissue infections but remained low in osteomyelitis. The kinetics of [

conclusionThe kinetics of [

Indexed as

Gallium RadioisotopesPositron-Emission TomographyRadioactive TracersSialic Acid Binding Immunoglobulin-like LectinsAnimalsBiomarkersKineticsMolecular ImagingOsteomyelitisPositron Emission Tomography Computed TomographySoft Tissue InfectionsSwineSwine DiseasesBiomarkersGallium RadioisotopesRadioactive TracersSialic Acid Binding Immunoglobulin-like Lectinsanimal modelgallium-68infectioninflammationkinetic analysisosteomyelitisSiglec-9Staphylococcus aureusVAP-1vascular adhesion protein

Identifiers

PMID31766140
PMCPMC6891593
OpenAlexW2987074759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.