Evidence map›Paper›PMID 31766138›Full record

ArticleViruses2019

Characterization of Brain Inflammation, Apoptosis, Hypoxia, Blood-Brain Barrier Integrity and Metabolism in Venezuelan Equine Encephalitis Virus (VEEV TC-83) Exposed Mice by In Vivo Positron Emission Tomography Imaging.

Thomas M Bocan, Robert G Stafford, Jennifer L Brown, Justice Akuoku Frimpong, Falguni Basuli, Bradley S Hollidge, Xiang Zhang, Natarajan Raju, Rolf E Swenson, Darci R Smith

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  18. Immunopathogenesis of alphaviruses.Advances in virus research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Thomas M BocanTranslational Sciences Directorate, Countermeasure Development Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Ft. Detrick, MD 21702, USA.
Robert G StaffordTranslational Sciences Directorate, Countermeasure Development Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Ft. Detrick, MD 21702, USA.
Jennifer L BrownFoundational Sciences Directorate, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Ft. Detrick, MD 21702, USA.
Justice Akuoku FrimpongFoundational Sciences Directorate, Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Ft. Detrick, MD 21702, USA.
Falguni BasuliImaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Bradley S HollidgeFoundational Sciences Directorate, Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Ft. Detrick, MD 21702, USA.
Xiang ZhangImaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Natarajan RajuImaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Rolf E SwensonImaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Darci R SmithImmunodiagnostic Department, Naval Medical Research Center, 8400 Research Plaza, Fort Detrick, MD 21702, USA.
United States Army Medical Research Institute of Infectious Diseases · USNational Heart Lung and Blood Institute · USNational Institutes of Health · USCherokee Nation · USGeneral Dynamics (United States) · USNaval Medical Research Command · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional pathogenesis studies of alphaviruses involves monitoring survival, viremia, and pathogen dissemination via serial necropsies; however, molecular imaging shifts this paradigm and provides a dynamic assessment of pathogen infection. Positron emission tomography (PET) with PET tracers targeted to study neuroinflammation (

Indexed as

ApoptosisEncephalitis Virus, Venezuelan EquinePositron-Emission TomographyAnimalsBiomarkersBlood-Brain BarrierDisease Models, AnimalEncephalomyelitis, Venezuelan EquineHorsesHypoxiaImage Processing, Computer-AssistedMicePositron Emission Tomography Computed TomographyRadiopharmaceuticalsBiomarkersRadiopharmaceuticals[18F]albumin[18F]CP-18[18F]DPA-714[18F]FDG[18F]FMISOalphavirusesapoptosisBBB integrityC3H/HeN miceglucose metabolismhypoxianeuroinflammationPET imagingVEEV TC-83Venezuelan equine encephalitis

Identifiers

PMID31766138
PMCPMC6893841
OpenAlexW2985189437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.