Evidence map›Paper›PMID 31765493›Full record

ArticleMagnetic resonance in medicine2020

Effect of mouse strain and diet on feasibility of MRI-based cell tracking in the liver.

Christiane L Mallett, Jeremy M L Hix, Matti Kiupel, Erik M Shapiro

Abstract read
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In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christiane L MallettDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan.ORCID 0000-0003-4615-8498
Jeremy M L HixDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan.
Matti KiupelVeterinary Diagnostic Laboratory, Michigan State University, East Lansing, Michigan.
Erik M ShapiroDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan.ORCID 0000-0002-0901-5781

Funding

Quantitative molecular and cellular MRI of hepatocyte transplantationR01DK107697 · NIDDK · MICHIGAN STATE UNIVERSITY · PI SHAPIRO, ERIK · 2015 to 2018
$2.1M
NIDDK NIH HHS R01 DK107697
6 · The paper itself

Abstract

purposeMRI-based cell tracking identifies the location of magnetically labeled cells with hypointense voxels. Here we demonstrate a strain-dependent effect of liver MRI background on the feasibility of MRI-based cell tracking of transplanted cells in the mouse liver.

methodsFVB mice (GFP-LUC and NOG) and C57BL/6 mice (GFP+ and wild-type) were fed 3 different diets with varying iron content. In vivo

results

conclusionStrain, diet, and age are important considerations for MRI-based cell tracking in the liver. If a model with excessive liver iron must be used, alternative imaging methods such as magnetic particle imaging can be considered.

Indexed as

Cell TrackingMagnetic Resonance ImagingAnimalsDietFeasibility StudiesLiverMiceMice, Inbred C57BLcell trackingferritinironlivermouse

Identifiers

PMID31765493
PMCPMC7047545

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.