ArticlePloS one2019
MARGO (Massively Automated Real-time GUI for Object-tracking), a platform for high-throughput ethology.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
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- The larvalbioRxiv : the preprint server for biology · 2026Article
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- The First of Us:bioRxiv : the preprint server for biology · 2025Article
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- Identifying links between cardiovascular disease and insomnia by modeling genes from a pleiotropic locus.Disease models & mechanisms · 2025Article
- The fruit fly,Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sex-Specific Effects of Social Environment on Behaviour and Their Correlations inEcology and evolution · 2025Article
- Spatiotemporal dynamics of locomotor decisions inbioRxiv : the preprint server for biology · 2024Article
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- Responses of different Drosophila species to temperature changes.The Journal of experimental biology · 2022Article
- A Markerless Pose Estimator Applicable to Limbless Animals.Frontiers in behavioral neuroscience · 2022Article
- Precise Quantification of Behavioral Individuality From 80 Million Decisions Across 183,000 Flies.Frontiers in behavioral neuroscience · 2022Article
- Mechanisms of Variability Underlying Odor-Guided Locomotion.Frontiers in behavioral neuroscience · 2022Review
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fast object tracking in real time allows convenient tracking of very large numbers of animals and closed-loop experiments that control stimuli for many animals in parallel. We developed MARGO, a MATLAB-based, real-time animal tracking suite for custom behavioral experiments. We demonstrated that MARGO can rapidly and accurately track large numbers of animals in parallel over very long timescales, typically when spatially separated such as in multiwell plates. We incorporated control of peripheral hardware, and implemented a flexible software architecture for defining new experimental routines. These features enable closed-loop delivery of stimuli to many individuals simultaneously. We highlight MARGO's ability to coordinate tracking and hardware control with two custom behavioral assays (measuring phototaxis and optomotor response) and one optogenetic operant conditioning assay. There are currently several open source animal trackers. MARGO's strengths are 1) fast and accurate tracking, 2) high throughput, 3) an accessible interface and data output and 4) real-time closed-loop hardware control for for sensory and optogenetic stimuli, all of which are optimized for large-scale experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.