Evidence map›Paper›PMID 31765394›Full record

ArticlePloS one2019

Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project.

Mary Grace Alwano, Pamela Bachanas, Lisa Block, Michelle Roland, Baraedi Sento, Stephanie Behel, Refeletswe Lebelonyane, Kathleen Wirth, Faith Ussery, William Bapati and 16 more

Registry-linked trialAbstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01965470 (Botswana Combination Prevention Project), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01965470 phase4completednot on this map

Botswana Combination Prevention Project: -Evaluation Protocol (Protocol #1): Research Design and Impact Evaluation -Closed Clinical Cohort Protocol (Protocol #3) Implementation, Monitoring and Evaluation of Combination HIV Prevention Interventions in Rural and Peri-Urban Communities in Botswana

TypeinterventionalSponsorCenters for Disease Control and PreventionRan2013 to 2018ConditionsHIVArmsCombination Prevention, Enhanced Care
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Mary Grace AlwanoU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Gaborone, Botswana.
Pamela BachanasU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Atlanta, Georgia, United States of America.ORCID 0000-0001-9408-9904
Lisa BlockNorthrop Grumman, Atlanta, Georgia, United States of America.
Michelle RolandU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Gaborone, Botswana.
Baraedi SentoTebelopele HIV Counseling and Testing Center, Gaborone, Botswana.
Stephanie BehelU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Atlanta, Georgia, United States of America.
Refeletswe LebelonyaneBotswana Ministry of Health and Wellness, Gaborone, Botswana.
Kathleen WirthHarvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Faith UsseryU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Atlanta, Georgia, United States of America.
William BapatiTebelopele HIV Counseling and Testing Center, Gaborone, Botswana.
Catherine Motswere-ChirwaU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Gaborone, Botswana.
William AbramsU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Gaborone, Botswana.
Gene UsseryNorthrop Grumman, Atlanta, Georgia, United States of America.
James A MillerNorthrop Grumman, Atlanta, Georgia, United States of America.
Ebi BileU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Gaborone, Botswana.
Peter FonjungoU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Atlanta, Georgia, United States of America.
Agisanag KgwaduTebelopele HIV Counseling and Testing Center, Gaborone, Botswana.
Molly Pretorius HolmeHarvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Lisetta Del CastilloU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Gaborone, Botswana.ORCID 0000-0001-8485-6452
Tendani GaolatheBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Kelebemang LemeTebelopele HIV Counseling and Testing Center, Gaborone, Botswana.
Nokuthula MajingoBotswana Ministry of Health and Wellness, Gaborone, Botswana.
Shahin LockmanHarvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Joseph MakhemaBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Naomi BockU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Atlanta, Georgia, United States of America.
Janet MooreU.S. Centers for Disease Control and Prevention, Division of Global HIV/AIDS, Atlanta, Georgia, United States of America.

Funding

Mentoring in Patient-Oriented HIV Research in the Era of Universal ARTK24AI131928 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAHIN LOCKMAN · 2017 to 2026
$1.9M
CGH CDC HHS U01 GH000447CGH CDC HHS U2G GH000073CGH CDC HHS U2G GH000419CGH CDC HHS U2G GH001911NIAID NIH HHS K24 AI131928PEPFAR
6 · The paper itself

Abstract

introductionAchieving widespread knowledge of HIV-positive status is a crucial step to reaching universal ART coverage, population level viral suppression, and ultimately epidemic control. We implemented a multi-modality HIV testing approach to identify 90% or greater of HIV-positive persons in the Botswana Combination Prevention Project (BCPP) intervention communities.

methodsBCPP is a cluster-randomized trial designed to evaluate the impact of combination prevention interventions on HIV incidence in 30 communities in Botswana. Community case finding and HIV testing that included home and targeted mobile testing were implemented in the 15 intervention communities. We described processes for identifying HIV-positive persons, uptake of HIV testing by age, gender and venue, characteristics of persons newly diagnosed through BCPP, and coverage of knowledge of status reached at the end of study.

resultsOf the 61,655 eligible adults assessed in home or mobile settings, 13,328 HIV-positive individuals, or 93% of the estimated 14,270 positive people in the communities were identified through BCPP. Knowledge of status increased by 25% over the course of the study with the greatest increases seen among men (37%) as compared to women (19%) and among youth aged 16-24 (77%) as compared to older age groups (21%). Although more men were tested through mobile than through home-based testing, higher rates of newly diagnosed HIV-positive men were found through home than mobile testing.

conclusionsEven when HIV testing coverage is high, additional gains can be made using a multi-modality HIV testing strategy to reach different sub-populations who are being missed by non-targeted program activities. Men and youth can be reached and will engage in community testing when services are brought to places they access routinely.

Indexed as

Health Knowledge, Attitudes, PracticeAdolescentAdultBotswanaFemaleHIV InfectionsHumansMaleMiddle AgedYoung Adult

Identifiers

PMID31765394
PMCPMC6876886

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.