Evidence map›Paper›PMID 31765114›Full record

ArticleJournal of psychiatry & neuroscience : JPN2020

Quantitative tractography reveals changes in the corticospinal tract in drug-naïve children with attention-deficit/hyperactivity disorder

Xuan Bu, Chuang Yang, Kaili Liang, Qingxia Lin, Lu Lu, Lianqing Zhang, Hailong Li, Yingxue Gao, Shi Tang, Xiaoxiao Hu and 4 more

Abstract read
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In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Maturational Indices of the Cognitive Control Network Are Associated with Inhibitory Control in Early Childhood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  9. Review
  10. The structural connectome in ADHD.Psychoradiology · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xuan BuFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Chuang YangFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Kaili LiangFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Qingxia LinFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Lu LuFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Lianqing ZhangFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Hailong LiFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Yingxue GaoFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Shi TangFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Xiaoxiao HuFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Yanlin WangFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Xinyu HuFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Meihao WangFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).
Xiaoqi HuangFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University West China Hospital, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China (Bu, Liang, Lu, Zhang, Li, Gao, Tang, Hu, Wang, Hu, Huang); the Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Yang, Lin); and the Department of Radiology, Wenzhou Medical University First Affiliated Hospital, Nan Bai Xiang, Wenzhou, Zhejiang 325003, China (Wang).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The specific role of the corticospinal tract with respect to inattention and impulsive symptoms in children with attention-deficit/hyperactivity disorder (ADHD) has been explored in the past. However, to our knowledge, no study has identified the exact regions of the corticospinal tract that are affected in ADHD. We aimed to determine comprehensive alterations in the white matter microstructure of the corticospinal tract and underlying neuropsychological substrates in ADHD. Methods: We recruited 38 drug-naïve children with ADHD and 34 typically developing controls. We employed a tract-based quantitative approach to measure diffusion parameters along the trajectory of the corticospinal tract, and we further correlated alterations with attention and response inhibition measures. Results: Compared with controls, children with ADHD demonstrated significantly lower fractional anisotropy and higher radial diffusivity at the level of cerebral peduncle, and higher fractional anisotropy at the level of the posterior limb of the internal capsule in the right corticospinal tract only. As well, increased fractional anisotropy in the posterior limb of the internal capsule was negatively correlated with continuous performance test attention quotients and positively correlated with reaction time on the Stroop Colour–Word Test; increased radial diffusivity in the right peduncle region was positively correlated with omissions in the Stroop test. Limitations: The sample size was relatively small. Moreover, we did not consider the different subtypes of ADHD and lacked sufficient power to analyze subgroup differences. Higher-order diffusion modelling is needed in future white matter studies. Conclusion: We demonstrated specific changes in the right corticospinal tract in children with ADHD. Correlations with measures of attention and response inhibition underscored the functional importance of corticospinal tract disturbance in ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityChildDiffusion Tensor ImagingFemaleHumansMaleNeuropsychological TestsPyramidal TractsStroop TestWhite Matter

Identifiers

PMID31765114
PMCPMC7828908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.