Evidence map›Paper›PMID 31765057›Full record

ArticleHuman brain mapping2020

Structural core of the executive control network: A high angular resolution diffusion MRI study.

Kai-Kai Shen, Thomas Welton, Matthew Lyon, Andrew N McCorkindale, Greg T Sutherland, Samantha Burnham, Jurgen Fripp, Ralph Martins, Stuart M Grieve

Abstract read
In one paragraph

Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Article
  5. Creativity: a (white) matter of connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kai-Kai ShenAustralian eHealth Research Centre, CSIRO, Floreat, Western Australia, Australia.ORCID 0000-0002-5956-501X
Thomas WeltonSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Matthew LyonSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Andrew N McCorkindaleSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Greg T SutherlandFaculty of Medicine and Health, Charles Perkins Centre and School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Samantha BurnhamAustralian eHealth Research Centre, CSIRO, Floreat, Western Australia, Australia.
Jurgen FrippAustralian eHealth Research Centre, CSIRO, Floreat, Western Australia, Australia.
Ralph MartinsDepartment of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia.
Stuart M GrieveSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-2712-157X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high-angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly-connected "structural core" of the ECN comprising three components: interhemispheric frontal connections, a fronto-parietal subnetwork and fronto-striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post-hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour.

Indexed as

AdolescentAdultAgedBrain MappingCognitionCohort StudiesConnectomeDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingExecutive FunctionFemaleFrontal LobeHumansMaleMiddle AgedNeostriatum

Identifiers

PMID31765057
PMCPMC7267982

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.