ArticleJournal of the American Geriatrics Society2020
Longitudinal Investigation of Older Adults' Ability to Self-Manage Complex Drug Regimens.
Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- A brief intervention to discontinue inappropriate z-hypnotics use by older patients in primary care: a randomised controlled trial.BMC primary care · 2026Trial
- Exploring the reasons for self-administration medication errors among illiterate and low-literate community-dwelling older adults with polypharmacy: a qualitative study.BMC geriatrics · 2024Article
- Managing medications among individuals with mild cognitive impairment and dementia: Patient-caregiver perspectives.Journal of the American Geriatrics Society · 2024Article
- Behavioral Science: Enhancing Our Approach to the Development of Effective Additional Risk Minimization Strategies.Drug safety · 2024Article
- Implications of the medication regimen complexity index score on hospital readmissions in elderly patients with heart failure: a retrospective cohort study.BMC geriatrics · 2023Article
- Medication Dosing Schedules, Medication Knowledge, and Dosing Errors of Adults Taking Complex Drug Regimens.Journal of health care for the poor and underserved · 2023Article
- Development of a medication literacy assessment instrument (MELIA) for older people receiving home care.Journal of advanced nursing · 2022Article
- Caregiver involvement in managing medications among older adults with multiple chronic conditions.Journal of the American Geriatrics Society · 2021Article
- Sex differences in multimorbidity and polypharmacy trends: A repeated cross-sectional study of older adults in Ontario, Canada.PloS one · 2021Article
- "What should I do when I get home?" treatment plan discussion at discharge between specialist physicians and older in-patients: mixed method study.BMC health services research · 2020Article
- Medication Complexity among Disadvantaged African American Seniors in Los Angeles.Pharmacy (Basel, Switzerland) · 2020Article
- Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Medication Adherence Scale (PMAS).Patient preference and adherence · 2020Article
- The Source of Purchased Medications and Its Impact on Medication Mistakes and Hospitalizations.Research in gerontological nursingArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesWe sought to investigate older patients' ability to correctly and efficiently dose multidrug regimens over nearly a decade and to explore factors predicting declines in medication self-management.
designLongitudinal cohort study funded by the National Institute on Aging.
settingOne academic internal medicine clinic and six community health centers.
participantsBeginning in 2008, 900 English-speaking adults, aged 55 to 74 years, were enrolled in the study, completing a baseline (T1) assessment. To date, 303 participants have completed the same assessment 9 years postbaseline (T4). MEASUREMENTS: At T1, subjects were given a standardized, seven-drug regimen and asked to demonstrate how they would take medicine over 24 hours. The number of dosing errors made and times per day that a participant would take medicine were recorded. Health literacy was measured via the Newest Vital Sign, and cognitive decline was measured by the Mini-Mental State Examination.
resultsParticipants on average made 2.9 dosing errors (SD = 2.5 dosing errors; range = 0-21 dosing errors) of 21 potential errors at T1 and 5.0 errors (SD = 2.1 errors; range = 1-18 errors; P < .001) at T4. In a multivariate model, limited literacy (β = .69; 95% confidence interval [CI] = .18-1.20; P = .01), meaningful cognitive decline (β = 1.72; 95% CI = .70-2.74; P = .01), number of chronic conditions (β = .21; 95% CI = .07-.34; P = .01), and number of baseline dosing errors (β = -.76; 95% CI = -.85 to -.67; P < .001) were significant, independent predictors of changes in dosing errors. Most patients overcomplicated their daily medication schedule; no sociodemographic characteristics were predictive of poor regimen organization in multivariate models. In a multivariate model, there were no significant predictors of changes in regimen consolidation over time, except regimen consolidation at T1.
conclusionsOlder patients frequently overcomplicated drug regimens and increasingly made more dosing errors over 9 years of follow-up. Patients with limited literacy, cognitive decline, and multimorbidity were at greatest risk for errors. J Am Geriatr Soc 68:569-575, 2020.
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