Evidence map›Paper›PMID 31764999›Full record

ReviewFEBS letters2019

Viral and cellular interactions during adenovirus DNA replication.

Matthew Charman, Christin Herrmann, Matthew D Weitzman

Open access · bronzeAbstract readReview
In one paragraph

Review in FEBS letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. Oncolytic viruses: advanced strategies in cancer therapy.Signal transduction and targeted therapy · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Mysteries of adenovirus packaging.Journal of virology · 2025
    Review
  11. Review
  12. Progress in African Swine Fever Vector Vaccine Development.International journal of molecular sciences · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matthew CharmanDivision of Protective Immunity and Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Christin HerrmannDivision of Protective Immunity and Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Matthew D WeitzmanDivision of Protective Immunity and Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-9713-167X
Children's Hospital of Philadelphia · US

Funding

Viral Modulation of Genetic StabilityR01CA097093 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WEITZMAN, MATTHEW D. · 2003 to 2019
$5.2M
Double-stranded RNA during DNA virus infectionR01AI145266 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI WEITZMAN, MATTHEW D. · 2019 to 2023
$3.0M
Adenovirus manipulation of cellular chromatin to overcome host responsesR01AI121321 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI WEITZMAN, MATTHEW D. · 2018 to 2022
$2.7M
NCI NIH HHS R01 CA097093NIAID NIH HHS R01 AI121321NIAID NIH HHS R01 AI145266
6 · The paper itself

Abstract

Adenoviruses represent ubiquitous and clinically significant human pathogens, gene-delivery vectors, and oncolytic agents. The study of adenovirus-infected cells has long been used as an excellent model to investigate fundamental aspects of both DNA virus infection and cellular biology. While many key details supporting a well-established model of adenovirus replication have been elucidated over a period spanning several decades, more recent findings suggest that we have only started to appreciate the complex interplay between viral genome replication and cellular processes. Here, we present a concise overview of adenovirus DNA replication, including the biochemical process of replication, the spatial organization of replication within the host cell nucleus, and insights into the complex plethora of virus-host interactions that influence viral genome replication. Finally, we identify emerging areas of research relating to the replication of adenovirus genomes.

Indexed as

Adenoviruses, HumanAdenovirus Infections, HumanCell NucleusGenome, ViralHost-Pathogen InteractionsHumansVirus ReplicationadenovirusDNAliquid-liquid phase separationviral replication compartmentvirus

Identifiers

PMID31764999
PMCPMC6928415
OpenAlexW2991287279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.