ArticleBrain : a journal of neurology2020
Revisiting 'brain modes' in a new computational era: approaches for the characterization of brain-behavioural associations.
Article in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- The relevance of rich club regions for functional outcome post-stroke is enhanced in women.Human brain mapping · 2023Trial
- How covariate control can bias our insights into brain architecture and pathology.Scientific reports · 2026Article
- Non-Verbal Working Memory in Post-Stroke Motor Aphasia: A Pilot Study Using the Tactual Span.Neurology international · 2025Article
- Analysis of clinical anatomical correlates of motor deficits in stroke by multivariate lesion inference based on game theory.Frontiers in neuroscience · 2025Article
- Connectomic stroke lesion measures provide no benefit over basic spatial lesion features in the prognosis of global stroke outcome measures.Brain communications · 2025Article
- Downstream network transformations dissociate neural activity from causal functional contributions.Scientific reports · 2024Article
- Ground-truth validation of uni- and multivariate lesion inference approaches.Brain communications · 2024Article
- Data-driven biomarkers better associate with stroke motor outcomes than theory-based biomarkers.Brain communications · 2024Article
- The need for hemispheric separation in pairwise structural disconnection studies.Human brain mapping · 2023Article
- Data-driven biomarkers outperform theory-based biomarkers in predicting stroke motor outcomes.bioRxiv : the preprint server for biology · 2023Article
- When Neural Activity Fails to Reveal Causal Contributions.bioRxiv : the preprint server for biology · 2023Article
- The elusive metric of lesion load.Brain structure & function · 2023Review
- Use of multi-perturbation Shapley analysis in lesion studies of functional networks: The case of upper limb paresis.Human brain mapping · 2023Article
- Interpreting and validating complexity and causality in lesion-symptom prognoses.Brain communications · 2023Review
- Right-side spatial neglect and white matter disconnection after left-hemisphere strokes.Brain structure & function · 2022Article
- Systematic perturbation of an artificial neural network: A step towards quantifying causal contributions in the brain.PLoS computational biology · 2022Article
- Representation of semantic typicality in brain activation in healthy adults and individuals with aphasia: A multi-voxel pattern analysis.Neuropsychologia · 2021Article
- Outcome after acute ischemic stroke is linked to sex-specific lesion patterns.Nature communications · 2021Article
- Game theoretical mapping of white matter contributions to visuospatial attention in stroke patients with hemineglect.Human brain mapping · 2020Article
- Reply: Inhibition between human brain areas or methodological artefact?Brain : a journal of neurology · 2020Article
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Abstract
The study of brain-function relationships is undergoing a conceptual and methodological transformation due to the emergence of network neuroscience and the development of multivariate methods for lesion-deficit inferences. Anticipating this process, in 1998 Godefroy and co-workers conceptualized the potential of four elementary typologies of brain-behaviour relationships named 'brain modes' (unicity, equivalence, association, summation) as building blocks able to describe the association between intact or lesioned brain regions and cognitive processes or neurological deficits. In the light of new multivariate lesion inference and network approaches, we critically revisit and update the original theoretical notion of brain modes, and provide real-life clinical examples that support their existence. To improve the characterization of elementary units of brain-behavioural relationships further, we extend such conceptualization with a fifth brain mode (mutual inhibition/masking summation). We critically assess the ability of these five brain modes to account for any type of brain-function relationship, and discuss past versus future contributions in redefining the anatomical basis of human cognition. We also address the potential of brain modes for predicting the behavioural consequences of lesions and their future role in the design of cognitive neurorehabilitation therapies.
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