ArticleMedicine2019
Observation of immediate and mid-term effects of partial spleen embolization in reducing hepatic venous pressure gradient.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Partial splenic embolization combined with endoscopic therapies and vasoconstrictive drugs reduces rebleeding in cirrhosis patients with acute variceal bleeding and hypersplenism: a multicenter randomized controlled trial.Journal of gastroenterology · 2023Trial
- Effects of partial splenic embolization and portosystemic shunt occlusion on portal venous hemodynamics using 4D flow MRI.Abdominal radiology (New York) · 2026Article
- Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE).BMC gastroenterology · 2021Article
- Short-term Effects of Hepatic Arterial Buffer Responses Induced by Partial Splenic Embolization on the Hepatic Function of Patients with Cirrhosis According to the Child-Pugh Classification.Internal medicine (Tokyo, Japan) · 2021Article
- Splenic non-infarction volume determines a clinically significant hepatic venous pressure gradient response to partial splenic embolization in patients with cirrhosis and hypersplenism.Journal of gastroenterology · 2021Article
- Splenic Artery Proximal Embolization after Ectopic Variceal Bleeding: A Case Report on Portal Hypertension Management.GE Portuguese journal of gastroenterologyArticle
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo observe the immediate and mid-term effects of partial spleen embolization (PSE) in reducing hepatic venous pressure gradient (HVPG) in patients with cirrhotic esophagogastric varices.
methodsPatients diagnosed with cirrhosis and esophagogastric varices in our hospital between July 2016 and March 2018 were consecutively selected. Forty-three patients were selected based on the eligibility criteria to undergo PSE. The change in HVPG 5 minutes before and after embolization, was used to determine the immediate effect of PSE on HVPG reduction. HVPG was retested after 6 months to observe the change in the antihypertensive effect along with time.
resultsForty-three patients successfully underwent PSE and HVPG measurements. The HVPG was 17.7 ± 3.9 mmHg and 13.9 ± 3.1 mmHg before and after PSE, respectively, showing a significant decrease (21.5%, P < .05). Among them, 18 cases were retested for HVPG at 6 months after PSE, and the results showed significant differences in the HVPG levels before, immediately and 6 months after PSE. Compared with preoperative PSE, HVPG was decreased by 22.9% and 17.7% (P < 0.05) immediately and at 6 months after operation, respectively. There was no significant change at 6 months after PSE when compared with immediate postoperative PSE. No serious complications were observed in patients during their postoperative hospital stay.
conclusionPSE immediately reduced the portal pressure, and HVPG remained stable at 6 months after surgery. PSE is considered as a safe and easy to implement method, and is expected to be one of the treatments for reducing the portal pressure.
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