Evidence map›Paper›PMID 31764608›Full record

Observational studyJournal of developmental and behavioral pediatrics : JDBP2019

Psychiatric Symptoms: Prevalence, Co-occurrence, and Functioning Among Extremely Low Gestational Age Newborns at Age 10 Years.

Yael Dvir, Jean A Frazier, Robert M Joseph, Irina Mokrova, Phoebe S Moore, T Michael OʼShea, Stephen R Hooper, Hudson P Santos, Karl Kuban, ELGAN Study Investigators

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of developmental and behavioral pediatrics : JDBP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
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  11. Health-related quality of life of children born very preterm: a multinational European cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
  12. Article
  13. Psychiatric Outcomes, Functioning, and Participation in Extremely Low Gestational Age Newborns at Age 15 Years.Journal of the American Academy of Child and Adolescent Psychiatry · 2022
    Article
  14. Extreme prematurity: Risk and resiliency.Current problems in pediatric and adolescent health care · 2022
    Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yael DvirUniversity of Massachusetts Medical School, Worcester, MA.
Jean A FrazierUniversity of Massachusetts Medical School, Worcester, MA.
Robert M JosephBoston University School of Medicine, Boston, MA.
Irina MokrovaUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Phoebe S MooreUniversity of Massachusetts Medical School, Worcester, MA.
T Michael OʼSheaUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Stephen R HooperUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Hudson P SantosUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Karl KubanBoston University School of Medicine, Boston, MA.
ELGAN Study Investigators

Funding

Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0M
SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
The Role of the Placenta-Brain Axis in Children's NeurodevelopmentUH3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rebecca Fry, Michael O'SHEA · 2018 to 2026
$21.9M
Environment, Epigenetics, Neurodevelopment & Health of Extremely Preterm ChildrenUG3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2016 to 2024
$7.4M
Placental Epigenome and Brain Dysfunction after Preterm BirthR01HD092374 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2017 to 2021
$3.2M
Placental DNA Methylation, Maternal Hardship and Child Neurodevelopmental OutcomesK23NR017898 · NINR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SANTOS, HUDSON · 2018 to 2020
$395k
NICHD NIH HHS P30 HD018655NICHD NIH HHS R01 HD092374NIH HHS UG3 OD023348NIH HHS UH3 OD023348NINDS NIH HHS U01 NS040069NINR NIH HHS K23 NR017898
6 · The paper itself

Abstract

objectiveTo evaluate the percentage of children born extremely preterm (EP) who screen positive for ≥1 DSM-IV psychiatric disorders, the co-occurrence of and sex-related differences in these classifications, and the functional correlates of psychiatric symptoms.

methodsThe Extremely Low Gestational Age Newborn (ELGAN) Study is a prospective cohort follow-up of children born <28 weeks' gestation. For 871 10-year-old children, parents completed the Child Symptom Inventory-4 (CSI-4), a child educational/medical history questionnaire, and the Pediatric Quality of Life Inventory (PedsQL).

resultsAt age 10 years, ELGANs were more likely to screen positive for a number of psychiatric disorders when compared with normative expectations on the CSI-4, with a few sex-related differences. Fifteen percent of participants screened positive for 1 disorder, 7% for 2, 3% for 3, and 4% for ≥4 psychiatric disorders. Compared with children who did not screen positive for psychiatric disorders, children who screened positive for ≥3 psychiatric disorders were approximately twice as likely to have repeated a grade, have an individualized educational program, have an individual school aide, and to require special remediation classes. Children who screened positive for any psychiatric disorder were 4 times more likely to use 1 or more psychotropic medication, and those who screened positive for ≥2 psychiatric disorders had lower PedsQL scores.

conclusionAmong 10-year-old children born EP, rates of psychiatric symptoms exceeded normative expectation, and children who screened positive for more than 1 psychiatric disorder were at increased risk of having multiple functional impairments.

Indexed as

Infant, Extremely PrematureAcademic PerformanceChildComorbidityEducation, SpecialFemaleFollow-Up StudiesGestational AgeHumansMaleMental DisordersUnited States

Identifiers

PMID31764608
PMCPMC6884073

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.