Evidence map›Paper›PMID 31764270›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2019

Cascade Analysis: An Adaptable Implementation Strategy Across HIV and Non-HIV Delivery Platforms.

Anjuli D Wagner, Sarah Gimbel, Kristjana H Ásbjörnsdóttir, Peter Cherutich, Joana Coutinho, Jonny Crocker, Emilia Cruz, Fatima Cuembelo, Vasco Cumbe, McKenna Eastment and 27 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05002322 (Scaling Out and Scaling Up the Systems Analysis and Improvement Approach to Optimize the Hypertension Diagnosis and Care Cascade for HIV-infected Individuals), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05002322 nacompletednot on this mapstarted 2023, after this paper: background citation

Scaling Out and Scaling Up the Systems Analysis and Improvement Approach to Optimize the Hypertension Diagnosis and Care Cascade for HIV-infected Individuals

TypeinterventionalSponsorEduardo Mondlane UniversityRan2023 to 2025Enrolled18ConditionsHypertensionArmsSystems Analysis and Improvement Approach
3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Anjuli D Wagner
Sarah GimbelChild, Family, and Population Health Nursing, University of Washington, Seattle, WA.
Kristjana H ÁsbjörnsdóttirDepartment of Epidemiology, University of Washington, Seattle, WA.
Peter CherutichMinistry of Health, Nairobi, Kenya.
Joana CoutinhoHealth Alliance International, Beira, Mozambique.
Jonny Crocker
Emilia CruzHealth Alliance International, Beira, Mozambique.
Fatima CuembeloCommunity Health Department, Eduardo Mondlane University, Maputo, Mozambique.
Vasco CumbeDepartment of Mental Health, Sofala Provincial Health Directorate, Ministry of Health, Beira, Mozambique.
McKenna EastmentDepartment of Medicine, University of Washington, Seattle, WA.
Jennifer EinbergIota Ink, Seattle, WA.
Florencia FlorianoHealth Alliance International, Beira, Mozambique.
Douglas GaithoNetwork of AIDS Researchers of East and Southern Africa, Nairobi, Kenya.
Brandon L GuthrieDepartment of Epidemiology, University of Washington, Seattle, WA.
Grace John-StewartDepartment of Epidemiology, University of Washington, Seattle, WA.
Alex H KralCommunity Health and Implementation Research Program, RTI International, San Francisco, CA.
Barrot H LambdinCommunity Health and Implementation Research Program, RTI International, San Francisco, CA.
Shan LiuDepartment of Industrial and Systems Engineering, University of Washington, Seattle, WA.
Martin MainaNetwork of AIDS Researchers of East and Southern Africa, Nairobi, Kenya.
Nelia ManacaHealth Alliance International, Beira, Mozambique.
Mika MatsuzakiHarvard T.H. Chan School of Public Health, Boston, MA.
Loris MattoxHIV Education and Prevention Project of Alameda County, Oakland CA.
Nancy MburuNetwork of AIDS Researchers of East and Southern Africa, Nairobi, Kenya.
R Scott McClellandDepartment of Epidemiology, University of Washington, Seattle, WA.
Mark A MicekDepartment of Medicine, University of Wisconsin School of Medicine and Public Health.
Ana Olga MocumbiFaculty of Medicine, Universidade Eduardo Mondlane, Division of Non Communicable Diseases, Instituto Nacional de Saúde, Maputo, Mozambique.
Alberto MuanidoHealth Alliance International, Beira, Mozambique.
Ruth NduatiNetwork of AIDS Researchers of East and Southern Africa, Nairobi, Kenya.
Irene N NjugunaDepartment of Epidemiology, University of Washington, Seattle, WA.
Geoffrey OluochNetwork of AIDS Researchers of East and Southern Africa, Nairobi, Kenya.
Laura B OyiengoMinistry of Health, Nairobi, Kenya.
Keshet Ronen
Caroline Soi
Bradley H WagenaarHealth Alliance International, Seattle, WA.
George WanjeDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
Lynn D WengerCommunity Health and Implementation Research Program, RTI International, San Francisco, CA.
Kenneth SherrDepartment of Epidemiology, University of Washington, Seattle, WA.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
NPGH LEADERs YR12: OBSSR (Greenberg, Ngwafong Mukere) & NIBIB (Lee)D43TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI Dibyadyuti Datta, Chandy C. John · 2017 to 2026
$15.2M
Northern/Pacific Universities Global Health Research Training ConsortiumR25TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI KOLARS, JOSEPH C., NERURKAR, VIVEK RAMCHANDRA · 2012 to 2016
$5.9M
Systems Analysis and Improvement Approach to Optimize the Hypertension Diagnosis and Care Cascade for HIV-infected Individuals (SAIA-HTN)R01HL142412 · NHLBI · UNIVERSITY OF WASHINGTON · PI GIMBEL, SARAH ODELL · 2019 to 2023
$3.4M
Scaling up the systems analysis and improvement approach for prevention of mother-to-child HIV transmission in Mozambique (SAIA-SCALE)R01MH113435 · NIMH · UNIVERSITY OF WASHINGTON · PI SHERR, KENNETH · 2017 to 2021
$3.0M
Systems Analysis and Improvement to Optimize pMTCT: A Cluster Randomized TrialR01HD075057 · NICHD · UNIVERSITY OF WASHINGTON · PI SHERR, KENNETH · 2012 to 2014
$1.4M
RCT of an Implementation Science Tool to Integrate HIV testing into Family Planning Services K24HD088229 · NICHD · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, RAYMOND SCOTT · 2016 to 2020
$863k
Randomized controlled trial of an implementation science tool to increase cervical cancer screening in Mombasa, KenyaK08CA228761 · NCI · UNIVERSITY OF WASHINGTON · PI EASTMENT, MCKENNA CLAIRE · 2018 to 2022
$756k
Strengthening the identification and treatment of depression in primary care in MozambiqueK01MH110599 · NIMH · UNIVERSITY OF WASHINGTON · PI WAGENAAR, BRADLEY · 2017 to 2020
$633k
Systems analysis and improvement approach to optimize the pediatric HIV diagnosis and care cascade (SAIA-PEDS)R34AI129900 · NIAID · UNIVERSITY OF WASHINGTON · PI SHERR, KENNETH · 2017 to 2019
$622k
Optimizing Overdose Education and Naloxone Distribution Delivery in the United StatesR21DA046703 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI LAMBDIN, BARROT HOPKINS · 2018 to 2019
$455k
FIC NIH HHS D43 TW009345FIC NIH HHS R25 TW009345NCI NIH HHS K08 CA228761NHLBI NIH HHS R01 HL142412NIAID NIH HHS P30 AI027757NIAID NIH HHS R21 AI124399NIAID NIH HHS R34 AI129900NIAID NIH HHS T32 AI007140NICHD NIH HHS F32 HD088204NICHD NIH HHS K24 HD088229NICHD NIH HHS R01 HD075057NIDA NIH HHS R21 DA046703NIMH NIH HHS K01 MH110599NIMH NIH HHS R01 MH113435NIMH NIH HHS R21 MH113691
6 · The paper itself

Abstract

backgroundCascades have been used to characterize sequential steps within a complex health system and are used in diverse disease areas and across prevention, testing, and treatment. Routine data have great potential to inform prioritization within a system, but are often inaccessible to frontline health care workers (HCWs) who may have the greatest opportunity to innovate health system improvement.

methodsThe cascade analysis tool (CAT) is an Excel-based, simple simulation model with an optimization function. It identifies the step within a cascade that could most improve the system. The original CAT was developed for HIV treatment and the prevention of mother-to-child transmission of HIV.

resultsCAT has been adapted 7 times: to a mobile application for prevention of mother-to-child transmission; for hypertension screening and management and for mental health outpatient services in Mozambique; for pediatric and adolescent HIV testing and treatment, HIV testing in family planning, and cervical cancer screening and treatment in Kenya; and for naloxone distribution and opioid overdose reversal in the United States. The main domains of adaptation have been technical-estimating denominators and structuring steps to be binary sequential steps-as well as logistical-identifying acceptable approaches for data abstraction and aggregation, and not overburdening HCW. DISCUSSION: CAT allows for prompt feedback to HCWs, increases HCW autonomy, and allows managers to allocate resources and time in an equitable manner. CAT is an effective, feasible, and acceptable implementation strategy to prioritize areas most requiring improvement within complex health systems, although adaptations are being currently evaluated.

Indexed as

HIV InfectionsAdolescentAdultChildDelivery of Health Care, IntegratedEarly Detection of CancerFamily Planning ServicesFemaleHealth Plan ImplementationHealth Services ResearchHumansMaleMental Health ServicesMiddle AgedPregnancyPregnancy Complications, Infectious

Identifiers

PMID31764270
PMCPMC6880809

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.