Evidence map›Paper›PMID 31764259›Full record

ReviewJournal of acquired immune deficiency syndromes (1999)2019

Human-Centered Design Lessons for Implementation Science: Improving the Implementation of a Patient-Centered Care Intervention.

Laura K Beres, Sandra Simbeza, Charles B Holmes, Chanda Mwamba, Njekwa Mukamba, Anjali Sharma, Virginia Munamunungu, Monica Mwachande, Kombatende Sikombe, Carolyn Bolton Moore and 9 more

Erratum issued 2 registry-linked trialsAbstract readReview
In one paragraph

Review in Journal of acquired immune deficiency syndromes (1999), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06803316 completednot on this mapstarted 2022, after this paper: background citation

Optimizing Care Delivery to Support Reengagement in PLWH Returning to HIV Care After Treatment Lapses in Zambia

Typeobservational_patient_registrySponsorCentre for Infectious Disease Research in ZambiaRan2022 to 2025Enrolled658ConditionsHIV Antiretroviral Therapy (ART) Adherence
NCT07514221 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Adaptation of Project Yes+ to Improve Mental Health and Reduce HIV-related Stigma Among Adolescent and Young Men Who Have Sex With Men Living With HIV in Vietnam

TypeinterventionalSponsorHanoi Medical UniversityRan2026 to 2028Enrolled80ConditionsMental Disorder, HIV StigmaArmsTo-Hieu (I understand)
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it.

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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Laura K BeresDepartment of Interna6onal Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Sandra SimbezaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Charles B HolmesDepartment of Interna6onal Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Chanda MwambaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Njekwa MukambaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Anjali SharmaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Virginia MunamununguCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Monica MwachandeCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Kombatende SikombeCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Carolyn Bolton MooreCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Aaloke ModyUniversity of California San Francisco, San Francisco, CA.
Aybüke KoyuncuCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Katerina ChristopoulosUniversity of California San Francisco, San Francisco, CA.
Lazarus JereCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Jake PryCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Peter D EhrenkranzThe Bill & Melinda Gates Foundation, Seattle, WA.
Ashwin BuddenD'EVA Consulting, Washington, DC.
Elvin GengUniversity of California San Francisco, San Francisco, CA.
Izukanji SikazweCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.

Funding

Training in HIV Translational ResearchT32AI060530 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Diane V Havlir · 2005 to 2026
$6.4M
MENTORING MULTIDISCIPLINARY PATIENT-ORIENTED RESEARCH IN ENGAGEMENT IN HIV CAREK24AI134413 · NIAID · WASHINGTON UNIVERSITY · PI Elvin H. Geng · 2017 to 2026
$1.4M
Patterns and Factors Influencing Return to Care among HIV Patients in ZambiaF31MH109378 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BERES, LAURA · 2016 to 2019
$157k
NIAID NIH HHS K24 AI134413NIAID NIH HHS T32 AI060530NIMH NIH HHS F31 MH109378
6 · The paper itself

Abstract

backgroundEvidence-based HIV interventions often fail to reach anticipated impact due to insufficient utilization in real-world health systems. Human-centered design (HCD) represents a novel approach in tailoring innovations to fit end-users, narrowing the gap between efficacious interventions and impact at scale.

methodsWe combined a narrative literature review of HCD in HIV programs with our experience using HCD to redesign an intervention promoting patient-centered care (PCC) practices among health care workers (HCW) in Zambia. We summarize the use and results of HCD in the global HIV response and share case study insights to advance conceptualization of HCD applications.

resultsThe literature review identified 13 articles (representing 7 studies) on the use of HCD in HIV. All studies featured HCD hallmarks including empathy development, user-driven inquiry, ideation, and iterative refinement. HCD was applied to mHealth design, a management intervention and pre-exposure prophylaxis delivery. Our HCD application addressed a behavioral service delivery target: changing HCW patient-centered beliefs, attitudes, and practices. Through in-depth developer-user interaction, our HCD approach revealed specific HCW support for and resistance to PCC, suggesting intervention revisions to improve feasibility and acceptability and PCC considerations that could inform implementation in transferable settings.

conclusionsAs both a research and implementation tool, HCD has potential to improve effective implementation of the HIV response, particularly for product development; new intervention introduction; and complex system interventions. Further research on HCD application strengths and limitations is needed. Those promoting PCC may improve implementation success by seeking out resonance and anticipating the challenges our HCD process identified.

Indexed as

Health Plan ImplementationImplementation ScienceAttitude of Health PersonnelDelivery of Health CareHIV InfectionsHumansPatient-Centered Care

Identifiers

PMID31764259
PMCPMC6880397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.