ReviewCurrent opinion in critical care2020
Evolving targets for sedation during mechanical ventilation.
Review in Current opinion in critical care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Continuous ketamine infusion for surgical patients in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials with GRADE assessment.Critical care (London, England) · 2026Pooled it
- Risk factors for diaphragmatic dysfunction in mechanically ventilated patients: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Guideline
- Long-Term Sedation Effect of Cipepofol Compared to Dexmedetomidine in Patients Receiving Invasive Mechanical Ventilation: A Multicenter, Randomized, Open-Label, Parallel-Controlled Study.Advances in therapy · 2026Trial
- Ciprofol versus propofol for long-term sedation in mechanically ventilated patients with sepsis: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Sequential use of midazolam and dexmedetomidine for long-term sedation may reduce weaning time in selected critically ill, mechanically ventilated patients: a randomized controlled study.Critical care (London, England) · 2022Trial
- Physiology-guided mechanical ventilation: Monitoring, proportional assist, and bounded automation.World journal of critical care medicine · 2026Review
- Therapeutic coma in non-convulsive status epilepticus is associated with increased complications and mortality: a retrospective cohort study.Journal of neurology · 2026Article
- The cost analysis of remifentanil and fentanyl for analgosedation in mechanically ventilated patients in intensive care: Post hoc analysis of an open-labelled pilot randomised controlled study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Respiratory Rehabilitation and Decannulation in Adults with Prolonged Mechanical Ventilation After Tracheostomy: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Nurse-led glycemic control protocols in intensive care units: a scoping review.Acute and critical care · 2026Article
- Advantages of Ciprofol with Special Consideration of Pediatric Anesthesia.Children (Basel, Switzerland) · 2026Review
- Initial sedation strategy and clinical outcomes in mechanically ventilated neurocritical care patients with acute brain injury: a retrospective cohort study.Frontiers in medicine · 2026Article
- Resting energy expenditure changes related to different sedation levels in critically ill patients undergoing invasive mechanical ventilation.Frontiers in medicine · 2026Article
- Assessment of postoperative outcomes of prescription benzodiazepine use in lung transplant recipients.Journal of thoracic disease · 2025Article
- Analysis of Risk Factors and Development of a Predictive Model for Delirium in ICU Patients: Construction, Validation, and Clinical Implications.International journal of general medicine · 2025Article
- Effect of remimazolam besylate versus midazolam on time to extubation in critically ill, mechanically ventilated patients: a randomized controlled trial.Frontiers in medicine · 2025Article
- Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial.Therapeutics and clinical risk management · 2025Article
- Pharmacogenomic variation and sedation outcomes during early intensive care unit admission: A pragmatic study.Clinical and translational science · 2024Observational
- Ciprofol prevents ferroptosis in LPS induced acute lung injury by activating the Nrf2 signaling pathway.BMC pulmonary medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
purposes of reviewCritically ill patients frequently require mechanical ventilation as part of their care. Administration of analgesia and sedation to ensure patient comfort and facilitate mechanical ventilation must be balanced against the known negative consequences of excessive sedation. The present review focuses on the current evidence for sedation management during mechanical ventilation, including choice of sedatives, sedation strategies, and special considerations for acute respiratory distress syndrome (ARDS). RECENT
findingsThe Society of Critical Care Medicine recently published their updated clinical practice guidelines for analgesia, agitation, sedation, delirium, immobility, and sleep in adult patients in the ICU. Deep sedation, especially early in the course of mechanical ventilation, is associated with prolonged time to liberation from mechanical ventilation, longer ICU stays, longer hospital stays, and increased mortality. Dexmedetomidine may prevent ICU delirium when administered nocturnally at low doses; however, it was not shown to improve mortality when used as the primary sedative early in the course of mechanical ventilation, though the majority of patients in the informing study failed to achieve the prescribed light level of sedation. In a follow up to the ACURASYS trial, deep sedation with neuromuscular blockade did not result in improved mortality compared to light sedation in patients with severe ARDS. SUMMARY: Light sedation should be targeted early in the course of mechanical ventilation utilizing daily interruptions of sedation and/or nursing protocol-based algorithms, even in severe ARDS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.