Evidence map›Paper›PMID 31764098›Full record

Observational studyAIDS (London, England)2019

Non-AIDS comorbidity burden differs by sex, race, and insurance type in aging adults in HIV care.

Frank J Palella, Rachel Hart, Carl Armon, Ellen Tedaldi, Bienvenido Yangco, Richard Novak, Linda Battalora, Douglas Ward, Jun Li, Kate Buchacz and 1 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Trial
  2. Focusing on vulnerable populations in HIV.Chinese medical journal · 2026
    Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Changes in the Prevalence of Non-AIDS Conditions Among Hospitalized Persons With HIV in the United States and Canada, 2008-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4bioRxiv : the preprint server for biology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Frank J PalellaaNorthwestern University Feinberg School of Medicine, Chicago, Illinois bCerner Corporation, Kansas City, Missouri cTemple University School of Medicine, Philadelphia, Pennsylvania dInfectious Disease Research Institute, Inc., Tampa, Florida eUniversity of Illinois at Chicago, Chicago, Illinois fColorado School of Mines, Golden, Colorado gDupont Circle Physicians Group, Washington, District of Columbia hU.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Rachel Hart
Carl Armon
Ellen Tedaldi
Bienvenido Yangco
Richard Novak
Linda Battalora
Douglas Ward
Jun Li
Kate Buchacz
HIV Outpatient Study (HOPS)

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectiveTo understand the epidemiology of non-AIDS-related chronic comorbidities (NACMs) among aging persons with HIV (PWH).

designProspective multicenter observational study to assess, in an age-stratified fashion, number and types of NACMs by demographic and HIV factors.

methodsEligible participants were seen during 1 January 1997 to 30 June 2015, followed for more than 5 years, received antiretroviral therapy (ART), and virally suppressed (HIV viral load <200 copies/ml ≥75% of observation time). Age was stratified (18-40, 41-50, 51-60, ≥61 years). NACMs included cardiovascular disease, cancer, hypertension, diabetes, dyslipidemia, arthritis, viral hepatitis, anemia, and psychiatric illness.

resultsOf 1540 patients, 1247 (81%) were men, 406 (26%) non-Hispanic blacks (NHB), 183 (12%) Hispanics/Latinos, 575 (37%) with public insurance, 939 (61%) MSM, and 125 (8%) with injection drug use history. By age strata 18-40, 41-50, 51-60, and at least 61 years, there were 180, 502, 560, and 298 patients, respectively. Median HIV Outpatient Study observation was 10.8 years (range: min-max = 5.0-18.5). Mean number of NACMs increased with older age category (1.4, 2.1, 3.0, and 3.9, respectively; P < 0.001), as did prevalence of most NACMs (P < 0.001). Age-related differences in NACM numbers were primarily due to anemia, hepatitis C virus infection, and diabetes. Differences (all P < 0.05) in NACM number existed by sex (women >men, 3.9 vs. 3.4), race/ethnicity (NHB >non-NHB, 3.8 vs. 3.4), and insurance status (public >private, 4.3 vs. 3.1).

conclusionsAge-related increases existed in prevalence and number of NACMs, with disproportionate burden among women, NHBs, and the publicly insured. These groups should be targeted for screening and prevention strategies aimed at NACM reduction.

Indexed as

AgingComorbidityAdolescentAdultAgedAged, 80 and overAge DistributionAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountEthnicityFemaleHIV InfectionsHomosexuality, MaleHumansInsurance CoverageLogistic Models

Identifiers

PMID31764098
PMCPMC12329769

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.