ArticleAmerican journal of clinical oncology2020
Tumor Deposits in Stage III Colon Cancer: Correlation With Other Histopathologic Variables, Prognostic Value, and Risk Stratification-Time to Consider "N2c".
Article in American journal of clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- Combining tumor deposits with the number of lymph node metastases to improve the prognostic accuracy in stage III colon cancer: a post hoc analysis of the CALGB/SWOG 80702 phase III study (Alliance)Annals of oncology : official journal of the European Society for Medical Oncology · 2021Trial
- Tumour deposits in colorectal carcinoma are associated with immune evasion and dose-dependent adverse prognosis beyond nodal status.British journal of cancer · 2026Article
- Prognostic importance of tumour deposits with and without concurrent lymph node metastases in patients with stage III colon cancer.BJS open · 2026Article
- Article
- Prognostic impact and clinical staging adjustment of tumor deposits in postoperative radioiodine therapy for differentiated thyroid cancer.Endocrine · 2025Article
- A prognostic nomogram based on desmoplastic reaction/tumor deposit modified lymph node staging in colorectal cancer.Journal of gastrointestinal oncology · 2025Article
- Prognostic significance of tumor deposit counts in stage III colorectal cancer based on T/N staging and chemotherapy status: A retrospective cohort study.Surgery open science · 2025Article
- Tumor deposits should not be placed in the M category of TNM: A comparative survival analysis using SEER data.International journal of cancer · 2025Article
- Dissecting the opposing regulatory functions of endogenous nitric oxide production in colorectal cancer initiation, adaptive immune response alterations, and ferroptosis execution.Oncology reviews · 2025Review
- Tumour deposit count is an independent prognostic factor in colorectal cancer-a population-based cohort study.The British journal of surgery · 2024Article
- The past, present, and future of tumour deposits in colorectal cancer: Advancing staging for improved prognosis and treatment decision-making.Journal of cellular and molecular medicine · 2024Review
- Evaluating the prognostic value of tumor deposits in non-metastatic lymph node-positive colon adenocarcinoma using Cox regression and machine learning.International journal of colorectal disease · 2024Article
- Combining pathological risk factors and T, N staging to optimize the assessment for risk stratification and prognostication in low-risk stage III colon cancer.World journal of surgical oncology · 2024Article
- Prognostic Value of Tumor Deposits in Patients with Colorectal Cancer.Journal of Cancer · 2024Article
- Negative prognostic impact of tumor deposits in stage III colorectal cancer patients.PloS one · 2024Article
- Tumour deposits in colon cancer predict recurrence and reduced survival in a nationwide population-based study.BJS open · 2023Article
- Multiregional-based magnetic resonance imaging radiomics model for predicting tumor deposits in resectable rectal cancer.Abdominal radiology (New York) · 2023Article
- Clinical significance of metastatic tumor deposit foci in rectal cancer in the lateral pelvic lymph node area.International journal of clinical oncology · 2023Article
- Risk factors predict microscopic extranodal tumor deposits in advanced stage III colon cancer patients.World journal of gastroenterology · 2023Article
- Adverse impact of tumor deposits in lymph node negative rectal cancer - a national cohort study.International journal of colorectal disease · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNational Comprehensive Cancer Network (NCCN) guidelines for stage III colon cancer define low-risk versus high-risk patients based on T (1 to 3 vs. 4) and N (1 vs. 2) status, with some variations in treatment. This study analyzes the impact of tumor deposits (TDs), T and N status, poor differentiation (PD), perineural invasion (PNI), and lymphovascular invasion (LVI) on survival. MATERIALS AND
methodsA retrospective analysis (2010-2015) of the National Cancer Database of stage III colon cancer patients treated with both surgery and chemotherapy was conducted. Data was extracted on sex, race, age at diagnosis, Charlson-Deyo Score, histopathologic variables, and survival rates. Statistical analysis used the test of proportions, log-rank test for Kaplan-Meier curves, and Cox proportional hazard models.
resultsFor the 42,901 patients analyzed, 5-year survival rates were similar for LNTD (59.8%) and LNTD (58.2%), but significantly worse for LNTD (41.5%) (P<0.001). The presence of LNTD was more often associated with T4 (36.9%), N2 (55.1%), PD (37.4%), PNI (34.5%), and LVI (69.1%), than LNTD or LNTD (P<0.001). The hazard ratios for each variable were: TD: 1.34; T4: 1.71; N2: 1.44; PD: 1.37; PNI: 1.11; LVI: 1.18. LN patients with ≥3 TD (N1c) had worse overall survival than those with 1 to 2 TD (P<0.01), but similar to ≥4 LNTD (N2) and 1 to 3 LNTD (N1a-b). In our model, 5-year survival ranged from 23.4% for high-risk to 78.1% for low-risk patients (P<0.001).
conclusionThis National Cancer Database (NCDB) analysis offers greater risk stratification and may prompt consideration of changes in American Joint Committee on Cancer (AJCC) classification (N2c, in addition to N1c) to reflect the different prognosis and guide management, as well as survivorship strategies, for TD stage III colon cancer patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.