Evidence map›Paper›PMID 31763730›Full record

ArticleMagnetic resonance in medicine2020

Triple diffusion encoding MRI predicts intra-axonal and extra-axonal diffusion tensors in white matter.

Sudhir Ramanna, Hunter G Moss, Emilie T McKinnon, Essa Yacoub, Joseph A Helpern, Jens H Jensen

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sudhir RamannaDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota.
Hunter G MossCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, South Carolina.
Emilie T McKinnonCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, South Carolina.
Essa YacoubDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota.
Joseph A HelpernCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, South Carolina.
Jens H JensenCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, South Carolina.ORCID 0000-0003-3219-4287

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Mehmet Akcakaya · 2019 to 2026
$11.7M
TRAINING PROGRAM FOR MEDICAL SCIENTISTST32GM008716 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DEMORE, NANCY · 1999 to 2024
$9.3M
Interdisciplinary Research Training in Otolaryngology and Communication SciencesT32DC014435 · NIDCD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DUBNO, JUDY R · 2015 to 2024
$2.9M
Advanced Diffusion MRI Applied in Hypoxic-ischemic NeonatesF31NS108623 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MOSS, HUNTER · 2019 to 2021
$123k
NIBIB NIH HHS P41 EB027061NIDCD NIH HHS T32 DC014435NIGMS NIH HHS T32 GM008716NINDS NIH HHS F31 NS108623
6 · The paper itself

Abstract

purposeTo demonstrate how triple diffusion encoding (TDE) MRI can be applied to separately estimate the intra-axonal and extra-axonal diffusion tensors in white matter (WM).

methodsUsing a TDE pulse sequence with an axially symmetric b-matrix, diffusion MRI data were acquired at 3T for 3 healthy adults with an axial b-value of 4000 s/mm

resultsFrom the TDE data, the average intra-axonal diffusivity in WM was found to be 2.24 ± 0.18 µm

conclusionBy using a simple TDE pulse sequence with an axially symmetric b-matrix, the diffusion tensors for the intra-axonal and extra-axonal spaces can be separately estimated in adult WM. This allows one to determine compartment-specific diffusion properties for these 2 water pools.

Indexed as

White MatterAdultAnisotropyAxonsDiffusionDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingHumansaxially symmetricdiffusion tensorextra-axonalintra-axonaltriple diffusion encodingwhite matter

Identifiers

PMID31763730
PMCPMC7726210

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.