Evidence map›Paper›PMID 31763624›Full record

ArticleNeuro-oncology advances

Sox2

Daniel M Treisman, Yinghua Li, Brianna R Pierce, Chaoyang Li, Andrew P Chervenak, Gerald J Tomasek, Guillermina Lozano, Xiaoyan Zheng, Marcel Kool, Yuan Zhu

Open access · goldAbstract read
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Daniel M TreismanCellular and Molecular Biology Graduate Program, Ann Arbor, Michigan.
Yinghua LiGilbert Family Neurofibromatosis Institute, Washington, DC.
Brianna R PierceGilbert Family Neurofibromatosis Institute, Washington, DC.
Chaoyang LiGilbert Family Neurofibromatosis Institute, Washington, DC.
Andrew P ChervenakCellular and Molecular Biology Graduate Program, Ann Arbor, Michigan.
Gerald J TomasekDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
Guillermina LozanoDepartment of Molecular Genetics, Section of Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Xiaoyan ZhengDepartment of Anatomy and Cell Biology, The GW School of Medicine and Health Sciences, The GW Cancer Center, Washington, DC.
Marcel KoolDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Yuan ZhuCellular and Molecular Biology Graduate Program, Ann Arbor, Michigan.
University of Michigan · USCenter for Cancer Research · USChildren's National · USCancer Genetics (United States) · USGW Medical Faculty Associates · USHeidelberg University · DE

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3M
Cellular and molecular basis of malignant astrocytomaR01NS053900 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHU, YUAN · 2006 to 2010
$1.6M
NCI NIH HHS T32 CA009676NIGMS NIH HHS T32 GM007315NINDS NIH HHS R01 NS053900
6 · The paper itself

Abstract

backgroundHigh-intensity therapy effectively treats most

methodsUsing mouse SHH-MB models with different p53 activities, we investigated therapeutic efficacy by activating p53-mediated cell-cycle arrest versus p53-mediated apoptosis on radiation-induced recurrence.

resultsUpon radiation treatment, p53

conclusionsQuiescent Sox2

Indexed as

apoptosisgranule cell precursorneural precursorp53Sonic Hedgehog medulloblastoma

Identifiers

PMID31763624
PMCPMC6860004
OpenAlexW2975156715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.