Evidence map›Paper›PMID 31763622›Full record

ArticleACR open rheumatology2019

Association between Pre-Intervention Physical Activity Level and Treatment Response to Exercise Therapy in Persons with Knee Osteoarthritis - An Exploratory Study.

Alison H Chang, Jungwha Lee, Jing Song, Lori Lyn Price, Augustine C Lee, Kieran F Reid, Roger A Fielding, Jeffrey B Driban, William C Harvey, Chenchen Wang

Abstract read
In one paragraph

Article in ACR open rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Exercise for osteoarthritis of the knee.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alison H ChangDepartment of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0001-7309-9687
Jungwha LeeDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jing SongRheumatology Division, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Lori Lyn PriceInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA and Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.
Augustine C LeeCenter for Complementary and Integrative Medicine; Division of Rheumatology, Allergy & Immunology; Tufts Medical Center, Boston, MA, USA.
Kieran F ReidNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA.
Roger A FieldingNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA.
Jeffrey B DribanCenter for Complementary and Integrative Medicine; Division of Rheumatology, Allergy & Immunology; Tufts Medical Center, Boston, MA, USA.
William C HarveyCenter for Complementary and Integrative Medicine; Division of Rheumatology, Allergy & Immunology; Tufts Medical Center, Boston, MA, USA.
Chenchen WangCenter for Complementary and Integrative Medicine; Division of Rheumatology, Allergy & Immunology; Tufts Medical Center, Boston, MA, USA.

Funding

Tufts Clinical and Translational Science Institute (Pilot Supplement)UL1TR002544 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2018 to 2022
$50.2M
Tufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4M
Resource CoreP30AR072579 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Leena Sharma · 2017 to 2026
$8.3M
Tai Chi for Knee OsteoarthritisR01AT005521 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2010 to 2013
$2.4M
Mentoring and Research in Patient-Oriented Integrative MedicineK24AT007323 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2014 to 2023
$1.8M
NCATS NIH HHS UL1 TR001064NCATS NIH HHS UL1 TR002544NCCIH NIH HHS K24 AT007323NCCIH NIH HHS R01 AT005521NIAMS NIH HHS P30 AR072579
6 · The paper itself

Abstract

objectiveExamine whether pre-intervention physical activity (PA) level is associated with achieving a positive treatment response of pain and/or function improvement after a 12-week exercise intervention in participants with knee osteoarthritis (OA).

methodsWe performed a secondary analysis of a randomized, single-blind comparative effectiveness trial showing similar treatment effects between Tai Chi mind-body exercise and standard physical therapy intervention for knee OA. Baseline PA was assessed by Community Healthy Activities Model Program for Seniors (CHAMPS) Questionnaire and, in a subsample, by tri-axial accelerometers. OMERACT-OARSI dichotomous responder criteria was used for clinically meaningful improvement at follow-up. Associations between baseline self-reported PA by CHAMPS and outcomes of responders vs. non-responders (reference group) were assessed using logistic regressions, adjusting for demographic covariates. We compared objectively-measured PA by accelerometry between responders vs. non-responders using Wilcoxon tests.

resultsOur sample consisted of 166 participants with knee OA who completed both baseline and 12-week post-intervention evaluations: mean age 60.7 year (SD 10.5), BMI 32.4 kg/m

conclusionPre-intervention PA level (subjective report or objective measurement) was not associated with whether an individual will achieve favorable treatment outcomes after a 12-week exercise intervention, suggesting that regardless of pre-intervention PA level, individuals will likely benefit from structured exercise interventions.

Indexed as

ExerciseOMERACTOsteoarthritisPhysical Activity

Identifiers

PMID31763622
PMCPMC6857980

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.