Evidence map›Paper›PMID 31763559›Full record

ArticleACS omega2019

Controlled Release of Naringin in GelMA-Incorporated Rutile Nanorod Films to Regulate Osteogenic Differentiation of Mesenchymal Stem Cells.

Yangjie Shao, Dongqi You, Yiting Lou, Jianhua Li, Binbin Ying, Kui Cheng, Wenjian Weng, Huiming Wang, Mengfei Yu, Lingqing Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration.Frontiers in bioengineering and biotechnology · 2022
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yangjie ShaoThe Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Dongqi YouThe Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Yiting LouThe Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Jianhua LiHangzhou Dental Hospital, Hangzhou 310006, Zhejiang Province, China.
Binbin YingDepartment of Stomatology, The Affiliated Ningbo First Hospital, Zhejiang University, Ningbo 315010, Zhejiang Province, China.
Kui ChengSchool of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, Zhejiang Province, China.
Wenjian WengSchool of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, Zhejiang Province, China.
Huiming WangThe Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Mengfei YuThe Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Lingqing DongThe Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naringin, a Chinese herbal medicine, has been demonstrated to concentration-dependently promote osteogenic differentiation of mesenchymal stem cells (MSCs). However, it remains a challenge to load naringin on coatings for osteogenesis and further control the release kinetics. Here, we demonstrated that the release behavior of naringin on rutile nanorod films could be controlled by either mixing naringin with gelatin methacryloyl (GelMA) before spinning onto the films or soaking the obtained GelMA-incorporated films with the naringin solution to achieve the distinct degradation-type release and diffusion-type release, respectively. We further revealed that the naringin-loaded coatings facilitated adhesion, proliferation and late differentiation, and mineralization of MSCs. Our findings provided a novel strategy to engineer the coatings with controlled release of naringin and emphasized the bioactivity of naringin for the osteogenic differentiation of MSCs.

Identifiers

PMID31763559
PMCPMC6868884

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.