ArticleChemical engineering journal (Lausanne, Switzerland : 1996)2019
Microfluidic continuous flow synthesis of functional hollow spherical silica with hierarchical sponge-like large porous shell.
Article in Chemical engineering journal (Lausanne, Switzerland : 1996), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Binary mineral nanoparticles enable intravascular delivery of metal ions to tumors for metalloimmunotherapy.Nature communications · 2026Article
- Article
- Enlarged pore of worm mesoporous silica nanoparticles improves anti-inflammatory drug absorption.Drug delivery and translational research · 2023Article
- Chitosan, Chitosan/IgG-Loaded, and N-Trimethyl Chitosan Chloride Nanoparticles as Potential Adjuvant and Carrier-Delivery Systems.Molecules (Basel, Switzerland) · 2023Article
- Microfluidic Synthesis, Doping Strategy, and Optoelectronic Applications of Nanostructured Halide Perovskite Materials.Micromachines · 2022Review
- A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis.International journal of molecular sciences · 2022Review
- Microorganism-Templated Nanoarchitectonics of Hollow TiONanomaterials (Basel, Switzerland) · 2022Article
- An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine.Pharmaceutics · 2021Review
- Nanomaterials Synthesis through Microfluidic Methods: An Updated Overview.Nanomaterials (Basel, Switzerland) · 2021Review
- Synthesis and Surface Engineering of Inorganic Nanomaterials Based on Microfluidic Technology.Nanomaterials (Basel, Switzerland) · 2020Review
- Spherical Polyelectrolyte Brushes as Templates to Prepare Hollow Silica Spheres Encapsulating Metal Nanoparticles.Nanomaterials (Basel, Switzerland) · 2020Article
- Microfluidics for ZnO micro-/nanomaterials development: rational design, controllable synthesis, and on-chip bioapplications.Biomaterials science · 2020Review
- Microfluidics-enabled rational design of ZnO micro-/nanoparticles with enhanced photocatalysis, cytotoxicity, and piezoelectric properties.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2019Article
- Microfluidics for silica biomaterials synthesis: opportunities and challenges.Biomaterials science · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Microfluidics brings unique opportunities for engineering micro-/nanomaterials with well-controlled physicochemical properties. Herein, using a miniaturized multi-run spiral-shaped microreactor, we develop a flow synthesis strategy to continuously produce hollow spherical silica (HSS) with hierarchical sponge-like pore sizes ranging from several nanometers to over one hundred nanometers. The formation of HSS is realized by mixing two reactant flows, one containing cetyltrimethylammonium bromide (CTAB) and diluted ammonia and the other 1,3,5-trimethylbenzene (TMB) and diluted tetraethyl orthosilicate (TEOS), at a flow rate as high as 5 mL/min. The effect of the reactant concentration and the flow rate on the structural change of the resultant materials is examined. Functional small-sized nanoparticles (magnetic nanoparticle, quantum dot, and silver nanoparticle) can be separately assembled into HSS and high molecular weight protein (bovine serum albumin) can be successfully loaded into HSS and delivered into cancer cells afterward, making them promising in the fields of separation and purification, bioimaging, catalysis, and theranostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.