ArticleJournal of photochemistry and photobiology. A, Chemistry2019
Selective Detection of Human Serum Albumin by Near Infrared Emissive Fluorophores: Insights into Structure-property Relationship.
Article in Journal of photochemistry and photobiology. A, Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 37 citations in OpenAlex.
- Fluorescent biosensor based cerium-doped carbon quantum dots for albumin detection.RSC advances · 2026Article
- Exploring the Interaction Between the Newly Designed Antitumor Zn(II) Complex and CT-DNA/BSA: Spectroscopic Methods, DFT Computational Analysis, and Docking Simulation.Applied biochemistry and biotechnology · 2023Article
- In situ generation of a Zwitterionic fluorescent probe for detection of human serum albumin protein.Analytical biochemistry · 2022Article
- Evaluating the Merit of a Syringol Derived Fluorophore as a Charge Transfer Probe for Detection of Serum Albumins.Journal of photochemistry and photobiology. A, Chemistry · 2022Article
- Dual luminescent charge transfer probe for quantitative detection of serum albumin in aqueous samples.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2020Article
- Development of Human Serum Albumin Selective Fluorescent Probe Using Thieno[3,2-Sensors (Basel, Switzerland) · 2019Article
Corrections and comments
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3 authors at 2 institutions in 1 country.
Funding
Abstract
Two donor-acceptor fluorophores were prepared and tested for quantitative determination of HSA in aqueous samples. Fluorophores were non-emissive in polar solvents due to energy loss via non-radiative decays. Complexation of the fluorophores with HSA resulted multi-fold enhancement of emission in the red-near infrared (NIR) region. The emission intensity was linearly correlated to the amount of protein in the solution, which enabled us to develop calibration graphs for quantitative estimation of HSA in synthetic urine samples. Between the two fluorophores, the methoxy substituted fluorophore 1 selectively recognized HSA. It exhibited remarkable fluorescence enhancement with HSA over bovine serum albumin (BSA) and other globular proteins. The selective sensing aptitude of 1 was attributed to its restricted motions in the protein's microenvironment due to multiple non-covalent interactions, preventing energy loss by radiationless decay. The different recognition properties of the fluorophores were estimated by the steady-state fluorescence and molecular docking studies. These findings indicate that this class of fluorophores can be useful for quantitative estimation of HSA in biological urine and blood samples in clinical practice.
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Registered trials
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