Evidence map›Paper›PMID 31762453›Full record

ArticleJournal of visualized experiments : JoVE2019

Analysis of Hematopoietic Stem Progenitor Cell Metabolism.

Giorgia Scapin, Marie C Goulard, Priyanka R Dharampuriya, Jennifer L Cillis, Dhvanit I Shah

Abstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cancer stem cells and their role in metastasis.Central European journal of urology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Giorgia ScapinNationwide Children's Hospital; The Ohio State University College of Medicine; The Ohio State University Comprehensive Cancer Center.
Marie C GoulardNationwide Children's Hospital; The Ohio State University College of Medicine; The Ohio State University Comprehensive Cancer Center.
Priyanka R DharampuriyaNationwide Children's Hospital; The Ohio State University College of Medicine; The Ohio State University Comprehensive Cancer Center.
Jennifer L CillisNationwide Children's Hospital; The Ohio State University College of Medicine; The Ohio State University Comprehensive Cancer Center.
Dhvanit I ShahNationwide Children's Hospital; The Ohio State University College of Medicine; The Ohio State University Comprehensive Cancer Center; dhvanit.shah@nationwidechildrens.org.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Biomechanical Stimulation of Hemogenic Endothelial Cells to Develop Clinical-Grade Hematopoietic Stem CellsR01HL131645 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI SHAH, DHVANIT INDRAVADAN · 2016 to 2019
$1.6M
NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL131645
6 · The paper itself

Abstract

Hematopoietic stem progenitor cells (HSPCs) have distinct metabolic plasticity, which allows them to transition from their quiescent state to a differentiation state to sustain demands of the blood formation. However, it has been difficult to analyze the metabolic status (mitochondrial respiration and glycolysis) of HSPCs due to their limited numbers and lack of optimized protocols for non-adherent, fragile HSPCs. Here, we provide a set of clear, step-by-step instructions to measure metabolic respiration (oxygen consumption rate; OCR) and glycolysis (extracellular acidification rate; ECAR) of murine bone marrow-Lineage

Indexed as

AnimalsCell DifferentiationCell RespirationGlycolysisHematopoietic Stem CellsMiceMitochondriaOxidative PhosphorylationOxygen ConsumptionProto-Oncogene Proteins c-kitProto-Oncogene Proteins c-kit

Identifiers

PMID31762453
PMCPMC6897312

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.