Evidence map›Paper›PMID 31762303›Full record

ArticleAIDS research and human retroviruses2020

Short Communication: Low Muscle Mass Is Associated with Osteoporosis in Older Adults Living with HIV.

Krisann K Oursler, Ali Iranmanesh, Chani Jain, Kim L Birkett, Brandon C Briggs, Dorothy C Garner, John D Sorkin, Alice S Ryan

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02101060 (Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02101060 nacompletednot on this map

Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2014 to 2019Enrolled33ConditionsHIVArmsexercise
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Krisann K OurslerDepartment of Medicine, Virginia Tech Carilion School of Medicine, Roanoke, Virginia.
Ali IranmaneshSalem Veterans Affairs Medical Center, Salem, Virginia.
Chani JainSalem Veterans Affairs Medical Center, Salem, Virginia.
Kim L BirkettSalem Veterans Affairs Medical Center, Salem, Virginia.
Brandon C BriggsSalem Veterans Affairs Medical Center, Salem, Virginia.
Dorothy C GarnerDepartment of Medicine, Virginia Tech Carilion School of Medicine, Roanoke, Virginia.
John D SorkinBaltimore Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center at the VA Maryland Health Care System, Baltimore, Maryland.
Alice S RyanBaltimore Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center at the VA Maryland Health Care System, Baltimore, Maryland.
Salem VA Medical Center · USUniversity of Maryland, Baltimore · USUniversity of Virginia · USVirginia Tech · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2005 to 2019
$17.3M
Effect of Exercise Training on Inflammation and Function in HIV Infected VeteransI01RX000667 · VA · SALEM VA MEDICAL CENTER · PI OURSLER, KRISANN K, RYAN, ALICE S. · 2015 to 2019
–
NIA NIH HHS P30 AG028747NIDDK NIH HHS P30 DK072488RRD VA I01 RX000667
6 · The paper itself

Abstract

Sarcopenia, age-related low muscle mass and function, is a well-established independent risk factor for bone fracture in the geriatric population but is understudied in older people living with HIV (PLWH). The objective of this cross-sectional study was to investigate in older PLWH the relationship between muscle mass and bone mineral density (BMD). Sedentary PLWH who were ≥50 years of age, receiving antiretroviral therapy, and enrolled in an exercise intervention trial were included. Established definitions for sarcopenia and osteopenia/osteoporosis were applied to muscle mass data and BMD collected by dual-energy X-ray absorptiometry before exercise training. Participants were 93% male and 33% Caucasian race with median age 61 years, and median CD4 lymphocytes 707 cells/μL. The majority (64%) were overweight and obese by body mass index. Appendicular skeletal muscle index (ASMI) correlated with BMD at the femoral neck (

Indexed as

Bone DensityAbsorptiometry, PhotonBody Mass IndexCross-Sectional StudiesFemaleHIV InfectionsHumansMaleMiddle AgedMuscle, SkeletalOsteoporosisRandomized Controlled Trials as TopicRisk FactorsSarcopeniabone mineral densityfrailty fractureHIVosteoporosissarcopenia

Identifiers

PMID31762303
PMCPMC7185343
OpenAlexW2990849163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.