SynthesisOrthopaedic surgery2019
Comprehensive Comparison of Liposomal Bupivacaine with Femoral Nerve Block for Pain Control Following Total Knee Arthroplasty: An Updated Systematic Review and Meta-Analysis.
Synthesis in Orthopaedic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparison of liposomal bupivacaine and regular bupivacaine in the transversus abdominis plane for postoperative analgesia: an updated systematic review and meta-analysis.BMC anesthesiology · 2026Pooled it
- Administration with corticosteroid relieving pain following total knee arthroplasty: A meta-analysis.Medicine · 2020Pooled it
- Association of Liposomal Bupivacaine with Postoperative Pain, Opioid Consumption and Early Functional Exercise in Tibial Plateau Fracture: A Retrospective Cohort Study.Journal of pain research · 2026Article
- Liposomal bupivacaine in lower extremity arthroplasty: a comprehensive review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Admixture of Liposomal Bupivacaine and Bupivacaine Hydrochloride for Peripheral Nerve Blocks in Adolescents Undergoing Orthopedic Surgery: An Observational Cohort Study.Journal of clinical medicine · 2024Article
- Single-shot liposomal bupivacaine in place of rectus sheath catheters to provide non-opiate analgesia after laparotomy: a quality improvement project to reduce the need for ongoing nursing input.BMJ open quality · 2024Article
- A guide to regional analgesia for Total Knee Arthroplasty.EFORT open reviews · 2021Article
- Liposomal bupivacaine for prolonging analgesia with TAP blocks-two steps forward, one step back.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Article
- Practical Considerations for Liposomal Bupivacaine Use in Orthopaedic Surgery: A Clinical and Economic Analysis.JB & JS open accessReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To compare the efficacy of liposomal bupivacaine (LB) and femoral nerve block following total knee arthroplasty, we conducted this systematic review and meta-analysis. 11 trials with 2,908 patients were included in this study. The pooled data demonstrated that total morphine consumption equivalents during the hospital stay was significantly increased in FNB group. In addition, LB has significantly better outcome in view of the postoperative functional recovery, such as the odds of fall, the incidences of straight leg rise (SLR), the number of patients who can walk independently in the day of surgery,the ambulation distance at POD1, the number of patients discharged at POD1. Consistent with the faster functional recovery, liposomal bupivacaine shortens the length of hospital stay. However, there was no significant difference between LB and FNB in terms of Visual Analogue Score (VAS) during the hospital stay. All in all, liposomal bupivacaine has significantly better outcome in view of the postoperative functional recovery and the length of hospital stay compared with femoral nerve block following the total knee arthroplasty.
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Registered trials
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