Evidence map›Paper›PMID 31762152›Full record

ArticleClinical and translational science2020

Immunogenicity in Clinical Practice and Drug Development: When is it Significant?

Valentina Shakhnovich, Bernd Meibohm, Amy Rosenberg, Andrzej M Kierzek, Rachel Hasenkamp, Ryan S Funk, Craig J Thalhauser, Piet H van der Graaf, Yow-Ming C Wang, Lora Hamuro

Abstract read
In one paragraph

Article in Clinical and translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  5. Review
  6. Article
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  8. Review
  9. Article
  10. Article
  11. Untoward immune effects of modern medication.Journal of biomedical research · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valentina ShakhnovichChildren's Mercy Kansas City, Kansas City, Missouri, USA.
Bernd MeibohmDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Amy RosenbergFDA Division of Biotechnology Review and Research III, Office of Pharmaceutical Quality, Office of Biotechnology Products, CDER/FDA, Silver Spring, Maryland, USA.
Andrzej M KierzekCertara, Sheffield, UK.
Rachel HasenkampChildren's Mercy Kansas City, Kansas City, Missouri, USA.
Ryan S FunkDepartment of Pharmacy Practice, The University of Kansas, Kansas City, Kansas, USA.
Craig J ThalhauserQuantitative Clinical Pharmacology, Bristol-Myers Squibb, Princeton, New Jersey, USA.
Piet H van der GraafCertara, Canterbury, UK.
Yow-Ming C WangOffice of Clinical Pharmacology, OTS/CDER/FDA, Silver Spring, Maryland, USA.
Lora HamuroClinical Pharmacology & Pharmacometrics, Bristol-Myers Squibb, Princeton, New Jersey, USA.

Funding

Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Dingran Chang, Steven Allan Soper · 2019 to 2026
$21.5M
Institutional Career Development CoreKL2TR002367 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MATTHEW W MOSCONI, NICOLE L NOLLEN · 2017 to 2026
$7.3M
NCATS NIH HHS KL2 TR002367NCATS NIH HHS L40 TR000598NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Models, ImmunologicalAdaptive ImmunityBiological ProductsDrug DevelopmentDrug MonitoringDrug-Related Side Effects and Adverse ReactionsHumansMonitoring, ImmunologicRisk AssessmentSocieties, ScientificUnited StatesUnited States Food and Drug AdministrationBiological Products

Identifiers

PMID31762152
PMCPMC7070797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.