ArticleInternational journal of bipolar disorders2019
Association between decreased HDL levels and cognitive deficits in patients with bipolar disorder: a pilot study.
Article in International journal of bipolar disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older-Age Bipolar Disorder ISBD Task Forces.Bipolar disorders · 2026Pooled it
- Sex differences in prevalence and clinical correlates for psychotic symptoms in first-episode drug-naïve patients with bipolar disorder: a cross-sectional study.Annals of general psychiatry · 2026Article
- Thyroid Hormone Dysregulation and Lipid Metabolism Alterations in Bipolar Disorder: Associations With Manic Episodes, Aggressive Behaviour and Cognitive Impairment.Actas espanolas de psiquiatria · 2025Article
- Investigating the association of the plasma lipidomic profile with cognitive performance and genetic risk in the PsyCourse study.Translational psychiatry · 2025Article
- Prevalence and Clinically Related Factors of Hypertriglyceridemia in Patients with Bipolar Disorder in Anhui Province, China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- High-density lipoprotein is inversely associated with psychiatric symptoms across diagnoses in patients with general psychiatric disorders.Frontiers in psychiatry · 2025Article
- High-Density Lipoprotein Correlates with Cognitive Functioning in Schizophrenic Women.Brain sciences · 2024Article
- Association among abnormal glycolipids, reproductive hormones, and cognitive dysfunction in female patients with bipolar disorder.BMC psychiatry · 2024Article
- Quality of Life and Metabolic Indicators of Patients with Type 2 Diabetes: A Cross-Sectional Study in Iran.International journal of endocrinology · 2022Article
- Cognitive impairment in psychiatric diseases: Biomarkers of diagnosis, treatment, and prevention.Frontiers in cellular neuroscience · 2022Review
- Cognitive performance in older-age bipolar disorder: Investigating psychiatric characteristics, cardiovascular burden and psychotropic medication.Acta psychiatrica Scandinavica · 2021Article
- Dissociation Pattern in Default-Mode Network Homogeneity in Drug-Naive Bipolar Disorder.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCognitive deficits are common in patients with bipolar disorder (BD). Abnormal high density lipoprotein (HDL) levels have been implicated in cognitive deficits associated with ageing and neurodegenerative disorders. The present study aimed to investigate serum HDL levels, cognitive deficits and their association in patients with BD.
methodsThirty-seven patients with BD and 37 gender- and age-matched healthy controls (HCs) were recruited in a case-control study. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and serum HDL levels were measured using enzymatic colourimetry.
resultsThere was no difference in serum HDL levels between patients with BD and HCs after adjusting for gender, age, education and body mass index (BMI). Cognitive test scores in patients with BD were significantly lower than those in HCs except for the visuospatial/constructional index after adjusting for confounding variables. Serum HDL levels were positively correlated with RBANS total score and language score in patients with BD. Stepwise multiple regression analysis showed that serum HDL levels were significantly correlated with RBANS total score and subscale scores on immediate memory and language in patients with BD after adjusting for confounding factors.
conclusionsOur findings suggest that patients with BD had poorer cognitive performance than HCs except for the visuospatial/constructional domain, and decreased serum HDL levels were correlated with cognitive deficits, especially in immediate memory and language domains in patients with BD.
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