ArticleAging2019
Decreased inter-hemispheric interactions but increased intra-hemispheric integration during typical aging.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07077460 (Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Aging-related changes in cognitive flexibility: fMRI meta-analysis.Behavioral and brain functions : BBF · 2025Pooled it
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Trial
- Age-dependent modulations of hemispheric small-world networks in different eye states: resting-state electroencephalogram research.GeroScience · 2026Article
- Anterior Superior Longitudinal Fasciculus Microstructure Correlates With Bimanual Visuomotor Performance in Healthy Younger but Not Older Adults.The European journal of neuroscience · 2026Article
- Inter-Hemispheric Coordination and Ageing in Visual Working Memory: A Distributed Framework.Brain sciences · 2026Review
- Interhemispheric connectivity measured with transcranial magnetic stimulation and EEG as an objective marker of cognitive risk.Brain communications · 2026Article
- Labile iron overload reprograms microglia and neurons for lipid droplet synthesis in the aging brain.bioRxiv : the preprint server for biology · 2025Article
- Large-scale cortical functional networks are organized in structured cycles.Nature neuroscience · 2025Article
- The negative relationship between brain-age gap and psychological resilience defines the age-related neurocognitive status in older people.GeroScience · 2025Article
- Resting State Network Connectivity Patterns in Early Aging: Late Middle-age Adults Contrasted with Young Adults.Experimental neurobiology · 2024Article
- Exploration of resting-state brain functional connectivity as preclinical markers for arousal prediction in prolonged disorders of consciousness: A pilot study based on functional near-infrared spectroscopy.Brain and behavior · 2024Article
- The relationship between interhemispheric homotopic functional connectivity and left-right difference of intrahemispheric functional integration in the human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Virtual lesions in MEG reveal increasing vulnerability of the language network from early childhood through adolescence.Nature communications · 2023Article
- Musicianship-Related Structural and Functional Cortical Features Are Preserved in Elderly Musicians.Frontiers in aging neuroscience · 2022Article
- Review
- Integration and Segregation of Dynamic Functional Connectivity States for Mild Cognitive Impairment Revealed by Graph Theory Indicators.Contrast media & molecular imaging · 2021Article
- Age-Associated Differences of Modules and Hubs in Brain Functional Networks.Frontiers in aging neuroscience · 2020Article
- Multivariate Brain Functional Connectivity Through Regularized Estimators.Frontiers in neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal aging is known to be accompanied by decreased segregation across the whole-brain functional network, which is associated with cognitive decline. Although compelling evidence supports reduced segregation and increased integration in whole-brain functional connectivity with aging, the age effect on the reorganization of large-scale functional networks at the hemispheric level remains unclear. Here, we aimed to examine age-related differences in inter-hemispheric interactions and intra-hemispheric integration by using resting-state functional MRI data of a healthy adult lifespan sample. The results showed that age-related decreases in inter-hemispheric integration were found in entire functional networks in both hemispheres, except for the sensorimotor network (SMN) and posterior default mode network (DMN). Specifically, aging was accompanied by increasing inter-hemispheric segregation in the left frontoparietal network (FPN) and left ventral attention network (VAN), as well as right-brain networks located in the auditory network (AN), visual network (VN), and temporal parts of the DMN. Moreover, aging was associated with increasing intra-hemispheric integration within the bilateral VN and posterior DMN while decreasing intra-hemispheric integration within the right VAN. These remarkable changes with aging confirm that there are dynamic interactions between functional networks across the lifespan and provide a means of investigating the mechanisms of cognitive aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.