ArticleCurrent biology : CB2019
Defined Cell Types in Superior Colliculus Make Distinct Contributions to Prey Capture Behavior in the Mouse.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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Who cites it
102 citing papers in PubMed.
- PSD-95 drives binocular vision maturation critical for predation.bioRxiv : the preprint server for biology · 2026Article
- A standard model for the vertebrate retina.Vision research · 2026Article
- Mice use predictive environmental cues to adapt predatory behavior in hunting tasks of variable difficulty.bioRxiv : the preprint server for biology · 2026Article
- Spatial biases in visual feature representation of mouse dorsal lateral geniculate nucleus boutons.iScience · 2026Article
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
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- Filter, Detector, Predictor: The expanding repertoire of retinal computation in vertebrates.Vision research · 2026Review
- Visual field position shapes input sampling and output routing in the superior colliculus.bioRxiv : the preprint server for biology · 2026Article
- An attention-demanding hunting paradigm engages the superior colliculus-zona incerta circuit mediating analgesia in male mice.Nature communications · 2026Article
- Vision shapes neural maps of space through an ancient midbrain pathway.bioRxiv : the preprint server for biology · 2026Article
- An inhibitory brainstem pathway reduces visual detection during background motion.Nature communications · 2026Article
- Predictive pursuit emerges in high-dimensional recurrent neural networks.bioRxiv : the preprint server for biology · 2026Article
- The functional organization of retinal input to the mouse superior colliculus.bioRxiv : the preprint server for biology · 2026Article
- A collicular-hypothalamic pathway for social visual awareness.bioRxiv : the preprint server for biology · 2026Article
- CBLN2 promoter enables genetic access to wide-field neurons of the tree shrew superior colliculus.Cell reports methods · 2026Article
- Vision guides directed orienting movements during obstacle avoidance in mice.bioRxiv : the preprint server for biology · 2026Article
- Eye Opening Primes Synaptic Maturation by Enhancing AMPA Receptor-Mediated Transmission and Spinogenesis in the Developing Superior Colliculus.Molecular neurobiology · 2025Article
- Fundamental role of brain-organ interaction in behavior-driven holistic homeostasis.Fundamental research · 2025Review
- Functional specialisation of multisensory temporal integration in the mouse superior colliculus.Nature communications · 2025Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
The superior colliculus (SC) plays a highly conserved role in visual processing and mediates visual orienting behaviors across species, including both overt motor orienting [1, 2] and orienting of attention [3, 4]. To determine the specific circuits within the superficial superior colliculus (sSC) that drive orienting and approach behavior toward appetitive stimuli, we explored the role of three genetically defined cell types in mediating prey capture in mice. Chemogenetic inactivation of two classically defined cell types, the wide-field (WF) and narrow-field (NF) vertical neurons, revealed that they are involved in distinct aspects of prey capture. WF neurons were required for rapid prey detection and distant approach initiation, whereas NF neurons were required for accurate orienting during pursuit as well as approach initiation and continuity. In contrast, prey capture did not require parvalbumin-expressing (PV) neurons that have previously been implicated in fear responses. The visual coding and projection targets of WF and NF cells were consistent with their roles in prey detection versus pursuit, respectively. Thus, our studies link specific neural circuit connectivity and function with stimulus detection and orienting behavior, providing insight into visuomotor and attentional mechanisms mediated by superior colliculus.
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