ArticleCell metabolism2020
STAT3 Activation-Induced Fatty Acid Oxidation in CD8
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Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 245 papers.
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245citing papers in PubMed
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Who cites it
245 citing papers in PubMed.
- CD4Cell death & disease · 2022Trial
- Host metadherin coordinates hepatic lipid metabolism and CD8Cell metabolism · 2026Article
- Upadacitinib Restrains the Pathogenic Fitness of CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Immune checkpoints and immunoregulation in metabolic diseases and cancers: pathological mechanisms and therapeutic potential.Signal transduction and targeted therapy · 2026Review
- STAT3 suppresses palmitic acid-induced apoptosis and fatty acid oxidation dysfunction in bovine mammary epithelial cells by transcriptionally activating CPT1A.Science China. Life sciences · 2026Article
- Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Association of subcutaneous adiposity with survival outcomes in advanced biliary tract cancer treated with gemcitabine, cisplatin, and immune checkpoint inhibitor.Journal of gastroenterology · 2026Article
- Metabolic Bottlenecks and Opportunities: Reshaping the Tumor Microenvironment for Cancer Immunotherapy.Cells · 2026Review
- The interplay between lipid metabolism, cancer progression and anti-cancer immunity.Experimental & molecular medicine · 2026Review
- Advances in Lipid Metabolism Reprogramming in Hepatocellular Carcinoma.Journal of clinical and translational hepatology · 2026Review
- Elevated ferroptosis is associated with elevated T cells in patients with heat stroke.Molecular biology reports · 2026Article
- Tumor-derived PCSK9-enriched exosomes reprogram adipocytes to drive metabolic dysregulation and immune evasion in triple-negative breast cancer.Cell death & disease · 2026Article
- Leptin Signaling at the Crossroads of Obesity, Immunity, and Cancer: Mechanistic Insights and Therapeutic Implications.Biomolecules & therapeutics · 2026Review
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Obesity-derived metabolites modulate anti-tumor immunity in the tumor microenvironment: from mechanisms to clinical applications.BMC medicine · 2026Review
- Targeting caveolin-1: dual challenges in tumor immunity and drug therapy strategies.Cancer cell international · 2026Review
- Fatty acid metabolic reprogramming in the tumor microenvironment: Unraveling mechanisms and therapeutic prospects.Genes & diseases · 2026Review
- Lipid metabolism reprogramming shapes the immune landscape in the tumor microenvironment.Cellular & molecular immunology · 2026Review
- S1P-S1PR1 signaling impairs CD8EMBO reports · 2026Article
- JAK/STAT-mediated regulation of PD-L1 expression in breast cancer: Molecular mechanisms and implications for immunotherapy.iScience · 2026Review
185 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors.
Chunyan ZhangDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA. Electronic address: czhang@coh.org.
Chanyu YueDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA; Sorrento Therapeutics Inc. 4955 Directors PI, San Diego, CA 92121, USA.
Andreas HerrmannDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA; Sorrento Therapeutics Inc. 4955 Directors PI, San Diego, CA 92121, USA.
Jieun SongDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Colt EgelstonDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Tianyi WangDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Zhifang ZhangDepartment of Immunology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Wenzhao LiDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Heehyoung LeeDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Maryam AftabizadehDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Yi Jia LiDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Peter P LeeDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Stephen FormanDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Cancer Center, Duarte, CA 91010, USA.
George SomloDepartment of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Peiguo ChuDepartment of Pathology, City of Hope Medical Center, Duarte, CA 91010, USA.
Laura KruperDepartment of Surgery, City of Hope Medical Center, Duarte, CA 91010, USA.
Joanne MortimerDepartment of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Dave S B HoonDepartment of Translational Molecular Medicine, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA.
Wendong HuangDiabetes & Metabolism Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA.
Saul PricemanDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Cancer Center, Duarte, CA 91010, USA. Electronic address: spriceman@coh.org.
Hua YuDepartment of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA. Electronic address: hyu@coh.org.
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3MTransplant for Lymphoma:Therapy-Related LeukemiaP50CA107399 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI FORMAN, STEPHEN J, KWAK, LARRY W · 2004 to 2022
$35.5MMiRNAs in hepatocellular carcinoma development and treatmentR01CA139158 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, WENDONG, YU, HUA E · 2011 to 2021
$3.7MRole of Stat3 in Tumor Immune Evasion and Immune SuppressionR01CA122976 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI YU, HUA E · 2006 to 2015
$2.9MBile acids and metabolic surgeryR01DK124627 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, WENDONG · 2020 to 2024
$2.0MNCI NIH HHS P30 CA033572NCI NIH HHS P50 CA107399NCI NIH HHS R01 CA122976NCI NIH HHS R01 CA139158NIDDK NIH HHS R01 DK124627
Abstract
Although obesity is known to be critical for cancer development, how obesity negatively impacts antitumor immune responses remains largely unknown. Here, we show that increased fatty acid oxidation (FAO) driven by activated STAT3 in CD8
Indexed as
AdipocytesAdipose TissueAnimalsBreast NeoplasmsCarcinogenesisCD8-Positive T-LymphocytesCell LineCell ProliferationChromatin ImmunoprecipitationFatty AcidsFemaleGlycolysisHumansInterferon-gammaLeptinMiceFatty AcidsInterferon-gammaLeptinPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorSTAT3 protein, humanSTAT3 Transcription FactorCD8 T cellsFAOIFNγleptinobesityPD-1PyMT modelSTAT3tumor
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