ArticleCell2019
The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPR
Open access · greenAbstract read
In one paragraph
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 118 citations in OpenAlex.
- Combating ageing beyond the cell: Emerging roles of extracellular proteostasis.The FEBS journal · 2026Review
- From permeation enhancer to therapeutic enabler: Advances, applications, and translational perspectives in hyaluronidase-based drug delivery.Materials today. Bio · 2026Review
- ROS-responsive hydrogel microspheres deliver shTMEM2-loaded liposomes to suppress pyroptosis and ameliorate intervertebral disc degeneration.Journal of nanobiotechnology · 2026Article
- Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration.Science (New York, N.Y.) · 2026Article
- Article
- Distinct responses to non-autonomous UPRCommunications biology · 2025Article
- Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.PLoS biology · 2025Article
- Expression of CD44 and Its Spliced Variants: Innate and Inducible Roles in Nervous Tissue Cells and Their Environment.International journal of molecular sciences · 2025Review
- Cytokine-Induced Cytotoxicity and Extracellular Matrix Abnormalities in Hepatocytes Derived From RAD50-Interacting Protein 1-Deficient Induced Pluripotent Stem Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Review
- The Protective Role of DUSP4 in Retinal Pigment Epithelium Senescence and Degeneration.International journal of molecular sciences · 2025Article
- Cartilage-targeting peptide-modified cerium oxide nanoparticles alleviate oxidative stress and cartilage damage in osteoarthritis.Journal of nanobiotechnology · 2024Article
- Fission yeast Bsd1 is required for ER stress response in Ire1 independent manner.Molecular biology reports · 2024Article
- Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Article
- Sil1-deficient fibroblasts generate an aberrant extracellular matrix leading to tendon disorganisation in Marinesco-Sjögren syndrome.Journal of translational medicine · 2024Article
- Article
- Olfaction regulates peripheral mitophagy and mitochondrial function.Science advances · 2024Article
- Mechanical stress through growth on stiffer substrates impacts animal health and longevity inbioRxiv : the preprint server for biology · 2024Article
- Cancer immunometabolism: advent, challenges, and perspective.Molecular cancer · 2024Review
- Prospective observational study on biomarkers of response in pancreatic ductal adenocarcinoma.Nature medicine · 2024Observational
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Robert Thomas SchinzelHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Ryo Higuchi-SanabriaHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Ophir ShalemHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Erica Ann MoehleHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Brant Michael WebsterHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Larry JoeHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Raz Bar-ZivHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Phillip Andrew FrankinoHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Jenni DurieuxHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Corinne PenderHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Naame KeletHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Saranya Santhosh KumarCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Nupur SavaliaHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Hannah ChiHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Milos SimicHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Ngoc-Tram NguyenHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA.
Andrew DillinHoward Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Regenerative Medicine, Berkeley, CA 94720, USA; University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dillin@berkeley.edu.
University of California, Berkeley · USCalifornia Institute for Regenerative Medicine · USHoward Hughes Medical Institute · USChildren's Hospital of Philadelphia · US
Funding
Glial regulation of longevity through a transcellular unfolded protein responseR01AG059566 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2018 to 2022
$2.0MCell non-autonomous function of the unfolded protein responseR01AG042679 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2013 to 2017
$1.5MMore than just a load control: cytoskeletal form and function during agingR00AG065200 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIGUCHI-SANABRIA, RYO · 2021 to 2023
$747kDissecting the mechanisms that underlie mislocalization and aggregation of RNA binding proteins in neurodegenerative diseasesR03NS111447 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SHALEM, OPHIR · 2019 to 2019
$352kThe Cytoskeletal Stress Response: A Novel Facet to Protecting Cell Integrity during AgingF32AG053023 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HIGUCHI-SANABRIA, RYO · 2016 to 2018
$168kNIA NIH HHS F32 AG053023NIA NIH HHS R00 AG065200NIA NIH HHS R01 AG042679NIA NIH HHS R01 AG059566NINDS NIH HHS R03 NS111447
Abstract
Cells have evolved complex mechanisms to maintain protein homeostasis, such as the UPR
Indexed as
Unfolded Protein ResponseAnimalsCaenorhabditis elegansCell LineCell ProliferationDisease ResistanceEndoplasmic ReticulumEndoplasmic Reticulum StressFibroblastsHumansHyaluronoglucosaminidaseImmunity, InnateLongevityMembrane ProteinsModels, BiologicalMolecular WeightCEMIP2 protein, humanHyaluronoglucosaminidaseMembrane ProteinsagingCRISPR-Cas9endoplasmic reticulumextracellular matrixglucosaminoglycanimmune responseMAPK signalingstress response
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.