ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Prevention of Postoperative Delirium in Patients Undergoing Elective Surgery Using Multicomponent Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Brain and behavior · 2026Pooled it
- The complex interaction of genetics and delirium: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial.JAMA network open · 2026Trial
- Goal-directed therapy based on rScOTrials · 2022Trial
- Delirium and Increased Risk of Developing Dementia: An Emulated Target Trial Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Associations between polygenic risk scores for Alzheimer's disease and postoperative delirium risk.Journal of Alzheimer's disease : JAD · 2026Article
- Genetic and epigenetic insights into perioperative neurocognitive disorders: a narrative review.British journal of anaesthesia · 2026Review
- Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.British journal of anaesthesia · 2026Article
- Preoperative plasma glial fibrillary acidic protein and postoperative delirium in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- PreoperativeFrontiers in bioinformatics · 2026Review
- Low-grade, systemic inflammation and the risk of perioperative neurocognitive disorders in an observational study of older adults.Scientific reports · 2025Observational
- From Bench to Bedside: New Frontiers in Understanding and Treating Postoperative Delirium.Journal of clinical medicine · 2025Review
- Advances in research on the pathogenesis and signaling pathways associated with postoperative delirium (Review).Molecular medicine reports · 2025Review
- Development of a Machine Learning-Based Predictive Model for Postoperative Delirium in Older Adult Intensive Care Unit Patients: Retrospective Study.Journal of medical Internet research · 2025Article
- Postoperative sepsis-associated neurocognitive disorder: mechanisms, predictive strategies, and treatment approaches.Frontiers in medicine · 2025Review
- The Relationship between Delirium and Dementia.Seminars in neurology · 2024Review
- Cognitive and Cerebrospinal Fluid Alzheimer's Disease-related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls.Anesthesiology · 2024Article
- Sleep and circadian biomarkers of postoperative delirium (SLEEP-POD): protocol for a prospective and observational cohort study.BMJ open · 2024Article
- Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study.Heliyon · 2024Article
- Modeling genotype-protein interaction and correlation for Alzheimer's disease: a multi-omics imaging genetics study.Briefings in bioinformatics · 2024Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
introductionApolipoprotein E (APOE) status may modify the risk of postoperative delirium conferred by inflammation.
methodsWe tested whether APOE modifies the established association between C-reactive protein (CRP) and delirium incidence, severity, and duration in 553 noncardiac surgical patients aged 70 and older. High postoperative plasma CRP (≥234.12 mg/L) was defined by the highest sample-based quartile. Delirium was determined using the Confusion Assessment Method and chart review, and severity was determined by the Confusion Assessment Method-Severity score.
resultsAPOE ε4 carrier prevalence was 19%, and postoperative delirium occurred in 24%. The relationship between CRP and delirium incidence, severity, and duration differed by ε4 status. Among ε4 carriers, there was a strong relationship between high CRP (vs. low CRP) and delirium incidence (relative risk [95% confidence interval], 3.0 [1.4-6.7]); however, no significant association was observed among non-ε4 carriers (relative risk [95% CI], 1.2 [0.8-1.7]). DISCUSSION: Our findings raise the possibility that APOE ε4 carrier status may modify the relationship between postoperative day 2 CRP levels and postoperative delirium.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.