Evidence map›Paper›PMID 31761469›Full record

ArticleJournal of colloid and interface science2020

Preparation and evaluation of microfluidic magnetic alginate microparticles for magnetically templated hydrogels.

Ishita Singh, Christopher S Lacko, Zhiyuan Zhao, Christine E Schmidt, Carlos Rinaldi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of colloid and interface science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Size tunable fabrication of magnetic alginate microparticles using flow focusing microfluidics.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Natural-Based Biomaterials for Peripheral Nerve Injury Repair.Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ishita SinghDepartment of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA. Electronic address: singhi@ufl.edu.
Christopher S LackoJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA. Electronic address: christopherlacko@ufl.edu.
Zhiyuan ZhaoDepartment of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA. Electronic address: zhao1989@ufl.edu.
Christine E SchmidtJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA. Electronic address: schmidt@bme.ufl.edu.
Carlos RinaldiDepartment of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA. Electronic address: carlos.rinaldi@ufl.edu.

Funding

Magnetically Templated Regeneration Scaffolds for Nerve Injury RepairR21NS093239 · NINDS · UNIVERSITY OF FLORIDA · PI RINALDI-RAMOS, CARLOS M, SCHMIDT, CHRISTINE E · 2015 to 2016
$401k
NINDS NIH HHS R21 NS093239
6 · The paper itself

Abstract

Our aim is to develop a hydrogel-based scaffold containing porous microchannels that mimic complex tissue microarchitecture and provide physical cues to guide cell growth for scalable, cost-effective tissue repair. These hydrogels are patterned through the novel process of magnetic templating where magnetic alginate microparticles (MAMs) are dispersed in a hydrogel precursor and aligned in a magnetic field before hydrogel crosslinking and subsequent MAM degradation, leaving behind an aligned, porous architecture. Here, a protocol for fabricating uniform MAMs using microfluidics was developed for improved reproducibility and tunability of templated microarchitecture. Through iron quantification, we find that this approach allows control over magnetic iron oxide loading of the MAMs. Using Brownian dynamics simulations and nano-computed tomography of templated hydrogels to examine MAM chain length and alignment, we find agreement between simulated and measured areal densities of MAM chains. Oscillatory rheology and stress relaxation experiments demonstrate that magnetically templated microchannels alter bulk hydrogel mechanical properties. Finally, in vitro studies where rat Schwann cells were cultured on templated hydrogels to model peripheral nerve injury repair demonstrate their propensity for providing cell guidance along the length of the channels. Our results show promise for a micro-structured biomaterial that could aid in tissue repair applications.

Indexed as

Alginate microparticlesHyaluronic acidHydrogelMagnetic microparticlesPeripheral nerve repairTissue engineering

Identifiers

PMID31761469
PMCPMC6955151

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.