ArticleThe Journal of thoracic and cardiovascular surgery2020
Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine.
Article in The Journal of thoracic and cardiovascular surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Multiomics profiling reveals systemic biological responses to severe subacute exposure to heated tobacco products in rats.Scientific reports · 2025Article
- CRISPR-Cas Genome Editing inHuman gene therapy · 2024Article
- Recovery of extracorporeal lungs using cross-circulation with injured recipient swine.The Journal of thoracic and cardiovascular surgery · 2024Article
- Is timing everything? Examining operative time in lung transplants from 2006 to 2023.JHLT open · 2024Article
- Machine Perfusion and Bioengineering Strategies in Transplantation-Beyond the Emerging Concepts.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- De Novo Design and Development of a Nutrient-Rich Perfusate for Ex Vivo Lung Perfusion with Cell Culture Models.International journal of molecular sciences · 2023Article
- Design and Implementation of a Rat Ex Vivo Lung Perfusion Model.Journal of visualized experiments : JoVE · 2023Article
- Immune characterization of a xenogeneic human lung cross-circulation support system.Science advances · 2023Article
- Technique for xenogeneic cross-circulation to support human donor lungs ex vivo.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Differential early response of monocyte/macrophage subsets to intra-operative corticosteroid administration in lung transplantation.Frontiers in immunology · 2023Article
- Article
- Advances in lung bioengineering: Where we are, where we need to go, and how to get there.Frontiers in transplantation · 2023Review
- Initial experience: ex-vivo perfused pig kidney to study urinary oxalate excretion.Urolithiasis · 2022Article
- Ex-vivo lung perfusion therapies: do they add value to organ donation?Current opinion in organ transplantation · 2022Review
- Novel approaches for long-term lung transplant survival.Frontiers in immunology · 2022Review
- Immune and Genome Engineering as the Future of Transplantable Tissue.The New England journal of medicine · 2021Review
- A year in general thoracic surgery published in the Journal of Thoracic and Cardiovascular Surgery: 2020.The Journal of thoracic and cardiovascular surgery · 2021Article
- Harnessing organs-on-a-chip to model tissue regeneration.Cell stem cell · 2021Review
- Ex vivo repair of human donor lungs for transplantation.Nature medicine · 2020Article
- Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs.Nature medicine · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectivesLung remains the least-utilized solid organ for transplantation. Efforts to recover donor lungs with reversible injuries using ex vivo perfusion systems are limited to <24 hours of support. Here, we demonstrate the feasibility of extending normothermic extracorporeal lung support to 4 days using cross-circulation with conscious swine.
methodsA swine behavioral training program and custom enclosure were developed to enable multiday cross-circulation between extracorporeal lungs and recipient swine. Lungs were ventilated and perfused in a normothermic chamber for 4 days. Longitudinal analyses of extracorporeal lungs (ie, functional assessments, multiscale imaging, cytokine quantification, and cellular assays) and recipient swine (eg, vital signs and blood and tissue analyses) were performed.
resultsThroughout 4 days of normothermic support, extracorporeal lung function was maintained (arterial oxygen tension/inspired oxygen fraction >400 mm Hg; compliance >20 mL/cm H
conclusionsWe demonstrate feasibility of normothermic maintenance of extracorporeal lungs for 4 days by cross-circulation with conscious swine. Cross-circulation approaches could support the recovery of damaged lungs and enable organ bioengineering to improve transplant outcomes.
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