Evidence map›Paper›PMID 31761123›Full record

ReviewImmunology and allergy clinics of North America2020

Evolution of Immune Responses in Food Immunotherapy.

Johanna M Smeekens, Michael D Kulis

Abstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Peanut-Specific IgG4 and IgA in Saliva Are Modulated by Peanut Oral Immunotherapy.The journal of allergy and clinical immunology. In practice · 2022
    Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. The dilemma of open or double-blind food challenges in diagnosing food allergy in children: Design of the ALDORADO trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Review
  10. Relationship between Saliva and Sublingual Immunotherapy.Pathogens (Basel, Switzerland) · 2021
    Review
  11. Review
  12. Mechanisms of oral immunotherapy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Review
  13. Review
  14. Biomarkers in oral immunotherapy.Journal of Zhejiang University. Science. B
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Johanna M SmeekensUNC Department of Pediatrics, UNC Food Allergy Initiative, UNC Chapel Hill, 116 Manning Drive, Mary Ellen Jones Building, Room 3004, Chapel Hill, NC 27599, USA. Electronic address: smeeken3@email.unc.edu.
Michael D KulisUNC Department of Pediatrics, UNC Food Allergy Initiative, UNC Chapel Hill, 116 Manning Drive, Mary Ellen Jones Building, Room 3004, Chapel Hill, NC 27599, USA.

Funding

RESEARCH TRAINING IN ALLERGY AND CLINICAL IMMUNOLOGYT32AI007062 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David B. Peden, John W. Sleasman · 1985 to 2026
$6.1M
Sublingual Immunotherapy for Peanut AllergyR01AT004435 · NCCIH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BURKS, A. WESLEY · 2008 to 2018
$3.6M
Therapeutic DNA Vaccine for Shellfish AllergiesR03AI140161 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KULIS, MICHAEL DAVID · 2018 to 2019
$174k
NCCIH NIH HHS R01 AT004435NIAID NIH HHS R03 AI140161NIAID NIH HHS T32 AI007062
6 · The paper itself

Abstract

Food allergies are a growing public health concern affecting approximately 8% of children and 10% of adults in the United States. Several immunotherapy approaches are under active investigation, including oral immunotherapy, epicutaneous immunotherapy, and sublingual immunotherapy. Each of these approaches uses a similar strategy of administering small, increasing amounts of allergen to the allergic subject. Immunologic studies have described changes in the T-cell compartment, serum and salivary immunoglobulin profile, and mast cell and basophil degranulation status in response to allergens. This review highlights the immunologic changes induced by food allergen-specific immunotherapy and discusses future directions in this field.

Indexed as

AllergensAnimalsBasophilsCell DegranulationDesensitization, ImmunologicFood HypersensitivityHumansImmunoglobulin EMast CellsTh2 CellsAllergensImmunoglobulin EBasophilsFood allergyIgEIgG4ImmunotherapyMast cellsTh2

Identifiers

PMID31761123
PMCPMC7101075

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.