Evidence map›Paper›PMID 31760467›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

O Humbert, N Cadour, M Paquet, R Schiappa, M Poudenx, D Chardin, D Borchiellini, D Benisvy, M J Ouvrier, C Zwarthoed and 6 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05260606 (Imaging Biomarkers for Immune Checkpoint Inhibitor Treatment in Patients With Non-small Cell Lung Cancer), which is not on this map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05260606 unknown statusnot on this mapstarted 2022, after this paper: background citation

Imaging Biomarkers for Immune Checkpoint Inhibitor Treatment in Patients With Non-small Cell Lung Cancer: Prospective Observational Study

Typeobservational_patient_registrySponsorSamsung Medical CenterRan2022 to 2025Enrolled100ConditionsCarcinoma, Non-Small-Cell Lung, Immune Checkpoint InhibitorsArmsF-18 FDG PET/CT
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 88 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Abbreviated dynamic total-body [Quantitative imaging in medicine and surgery · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Repeated dynamic [European journal of nuclear medicine and molecular imaging · 2024
    Observational
  9. [European journal of nuclear medicine and molecular imaging · 2024
    Article
  10. Total metabolic tumor volume onJournal for immunotherapy of cancer · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Immune checkpoint inhibition: a future guided by radiology.The British journal of radiology · 2023
    Review
  16. Metabolic patterns on [European journal of nuclear medicine and molecular imaging · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

O HumbertDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France. olivier.humbert@univ-cotedazur.fr.ORCID http://orcid.org/0000-0003-4440-5416
N CadourDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France.
M PaquetDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France.
R SchiappaDepartment of Biostatistics, Centre Antoine-Lacassagne, UCA, Nice, France.
M PoudenxDepartment of Medical Oncology, Centre Antoine-Lacassagne, UCA, Nice, France.
D ChardinDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France.
D BorchielliniDepartment of Medical Oncology, Centre Antoine-Lacassagne, UCA, Nice, France.
D BenisvyDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France.
M J OuvrierDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France.
C ZwarthoedDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France.
A SchiazzaDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France.
M IlieLaboratory of Clinical and Experimental Pathology, Hospital-Integrated Biobank (BB-0033-00025), Nice Hospital University, FHU OncoAge, UCA, Nice, France.
H GhalloussiDepartment of Medical Oncology, Centre Antoine-Lacassagne, UCA, Nice, France.
P M KoulibalyDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France.
J DarcourtDepartment of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06189, Nice, France.
J OttoDepartment of Medical Oncology, Centre Antoine-Lacassagne, UCA, Nice, France.
Université Côte d'Azur · FRCentre Antoine Lacassagne · FRCenter for Economic and Policy Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis prospective study aimed (1) to assess the non-small cell lung cancer (NSCLC) evolutive patterns to immunotherapy using FDG-PET and (2) to describe their association with clinical outcome.

designFifty patients with metastatic NSCLC were included before pembrolizumab or nivolumab initiation. FDG-PET scan was performed at baseline and after 7 weeks of treatment (PET

resultsUsing PERCIST on PET

conclusionIn patients with a first PD on PERCIST and treatment continuation, a subsequent PET identifies more than half of them with iDR and PsPD, both patterns being strongly associated with a clinical benefit of immunotherapy.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsFluorodeoxyglucose F18HumansImmunotherapyPositron-Emission TomographyPositron Emission Tomography Computed TomographyProspective StudiesTreatment OutcomeFluorodeoxyglucose F18FDG PETImmunotherapyLung cancerMonitoringResponse

Identifiers

PMID31760467
OpenAlexW2990661227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.