Evidence map›Paper›PMID 31760442›Full record

ArticleWorld journal of urology2020

Fewer tumour draining sentinel nodes in patients with progressing muscle invasive bladder cancer, after neoadjuvant chemotherapy and radical cystectomy.

Julia Alvaeus, Robert Rosenblatt, Markus Johansson, Farhood Alamdari, Tomasz Jakubczyk, Benny Holmström, Tammer Hemdan, Ylva Huge, Firas Aljabery, Susanne Gabrielsson and 3 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Julia AlvaeusDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, 901 85, Umeå, Sweden.
Robert RosenblattDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, 901 85, Umeå, Sweden.
Markus JohanssonDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, 901 85, Umeå, Sweden.
Farhood AlamdariDepartment of Urology, Västmanland Hospital, Västerås, Sweden.
Tomasz JakubczykDepartment of Urology, Länssjukhuset Ryhov, Jönköping, Sweden.
Benny HolmströmDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Tammer HemdanDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Ylva HugeDivision of Urology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Firas AljaberyDivision of Urology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Susanne GabrielssonDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Katrine RiklundDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Ola WinqvistDepartment of Clinical Immunology, Karolinska University Hospital, Stockholm, Sweden.
Amir SherifDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, 901 85, Umeå, Sweden. amir.m.sherif@gmail.com.ORCID http://orcid.org/0000-0002-3675-3050
Umeå University · SELinköping University · SEUppsala University · SEKarolinska Institutet · SEKarolinska University Hospital · SEStockholm South General Hospital · SESundsvall Municipality · SEVästmanlands sjukhus Västerås · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the relationship between the number of tumour draining sentinel nodes (SNs) and pathoanatomical outcomes, in muscle-invasive bladder cancer (MIBC), in patients undergoing neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). MATERIALS AND

methodsIn an ongoing prospective multicenter study, we included 230 patients with suspected urothelial MIBC from ten Swedish urological centers. All underwent TURb and clinical staging. From the cohort, 116 patients with urothelial MIBC; cT2-cT4aN0M0, underwent radical cystectomy (RC) and lymphadenectomy with SN-detection (SNd). 83 patients received cisplatin-based NAC and 33 were NAC-naïve. The number and locations of detected SNs and non-SNs were recorded for each patient. The NAC treated patients were categorized by pathoanatomical outcomes post-RC into three groups: complete responders (CR), stable disease (SD) and progressive disease (PD). Selected covariates with possible impact on SN-yield were tested in uni -and multivariate analyses for NAC-treated patients only.

resultsIn NAC treated patients, the mean number of SNs was significantly higher in CR patients (3.3) and SD patients (3.6) compared with PD patients (1.4) (p = 0.034). In a linear multivariate regression model, the number of harvested nodes was the only independent variable that affected the number of SNs (p = 0.0004).

conclusionsThe number of tumor-draining SNs in NAC-treated patients was significantly lower in patients with progressive disease.

Indexed as

Chemotherapy, AdjuvantCystectomyAdultAgedAged, 80 and overDisease ProgressionFemaleHumansMaleMiddle AgedMuscle, SmoothNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm StagingProspective StudiesSentinel Lymph NodeCisplatinCystectomyNeoadjuvant therapySentinel lymph node biopsyUrinary bladder neoplasms

Identifiers

PMID31760442
PMCPMC7423786
OpenAlexW2990354344

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.